{"id":"W3132651865","doi":"10.1016/j.ijpddr.2021.02.004","title":"Evaluation of changes in drug susceptibility and population genetic structure in Haemonchus contortus following worm replacement as a means to reverse the impact of multiple-anthelmintic resistance on a sheep farm","year":2021,"lang":"en","type":"article","venue":"International Journal for Parasitology Drugs and Drug Resistance","topic":"Helminth infection and control","field":"Veterinary","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Burroughs Wellcome Fund","keywords":"Biology; Haemonchus contortus; Population; Levamisole; Anthelmintic; Genotyping; Albendazole; Ivermectin; Genotype; Genetics; Veterinary medicine; Immunology; Gene; Helminths; Zoology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002511727,0.0001927127,0.0002549544,0.0002422615,0.0001634954,0.0001974279,0.0001854532,0.0002979772,0.0003812009],"category_scores_gemma":[0.0003193652,0.0001098888,0.000164141,0.00009592214,0.0001509213,0.0001224061,0.0001128817,0.0002515106,0.00008923533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002037345,"about_ca_system_score_gemma":0.0001263276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001467805,"about_ca_topic_score_gemma":0.002996907,"domain_scores_codex":[0.9998666,0.00003196283,0.0000091887,0.00003469989,0.00003173521,0.00002584645],"domain_scores_gemma":[0.9997867,0.00003362068,0.00005935516,0.00001597977,0.00004353496,0.00006092589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003245903,0.0001915947,0.01662616,0.00001418175,0.00001892787,0.0001390197,0.0001178677,0.00008222221,0.9801356,0.00001235098,0.00001541063,0.002322094],"study_design_scores_gemma":[0.00004497844,0.008354864,0.816644,0.000008805071,0.00009911384,0.0005799845,0.0004025099,0.002966807,0.1702145,0.00003182427,0.0006342158,0.00001836733],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999827,0.00001858047,0.00008252257,0.000003478079,8.257012e-7,0.000004930334,0.00001566794,0.000001897772,0.00004515077],"genre_scores_gemma":[0.9990721,0.00003651504,0.0003214769,0.00001090292,0.000001851296,0.0000130796,0.0001095747,0.000002011197,0.0004323952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001467805,"threshold_uncertainty_score":0.002918541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02888778837394997,"score_gpt":0.3926482588304472,"score_spread":0.3637604704564973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}