{"id":"W3132666989","doi":"10.1016/j.bpj.2020.11.655","title":"Novel Insights into Substrate Binding and Transport by the SLC4 Transporters","year":2021,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Cotransporter; Protonation; Biophysics; Symporter; Binding site; Gating; Mutagenesis; Bicarbonate; Ion transporter; Biochemistry; Transporter; Crystallography; Stereochemistry; Ion; Sodium; Membrane; Mutation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003608311,0.0004313062,0.000589923,0.0002632469,0.000397721,0.001266309,0.0005545864,0.0008326506,0.001539893],"category_scores_gemma":[0.0003138165,0.0003419617,0.0003200596,0.0002500766,0.0005813265,0.001598996,0.0004161056,0.0008174571,0.0004164173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007001554,"about_ca_system_score_gemma":0.0003725395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001025007,"about_ca_topic_score_gemma":0.001050721,"domain_scores_codex":[0.9998425,0.00002851246,0.000009180298,0.0000282544,0.00004967349,0.00004182831],"domain_scores_gemma":[0.9998993,0.00003488029,0.00001496497,0.00001268525,0.00001730786,0.00002080413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004625076,0.0000585237,0.00216241,0.0001866238,0.00002951402,0.001094672,0.0001725256,0.002315192,0.9497235,0.0275263,0.0008237167,0.01544455],"study_design_scores_gemma":[0.0001079101,0.0004289995,0.01846025,0.00007881742,0.0000995374,0.004928075,0.0009408356,0.09148759,0.7949253,0.04700793,0.04140308,0.0001317849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.921252,0.01448633,0.04913085,0.005055094,0.0002037752,0.00002004567,0.000267309,0.0004014307,0.00918322],"genre_scores_gemma":[0.9823959,0.005616781,0.007970747,0.0005201668,0.00008239516,0.00001317567,0.000192706,0.0000628533,0.003145251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001539893,"threshold_uncertainty_score":0.005151451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00878536599983321,"score_gpt":0.2166215470216132,"score_spread":0.20783618102178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}