{"id":"W3132688716","doi":"10.1096/fj.202002350r","title":"Aryl hydrocarbon receptor deficiency causes the development of chronic obstructive pulmonary disease through the integration of multiple pathogenic mechanisms","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Klox Technologies (Canada); St. Joseph’s Healthcare Hamilton; McMaster University; St. Paul's Hospital; CIS Scientific; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; McGill University; University of British Columbia Hospital; McGill University Health Centre","funders":"Institute of Circulatory and Respiratory Health; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; Canada Foundation for Innovation; National Institutes of Health; Canada Research Chairs; Fonds de Recherche du Québec - Santé; Université Laval; Michael Smith Health Research BC; Government of Canada; Canadian Institutes of Health Research; Teva Pharmaceutical Industries; McGill University Health Centre; Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Aryl hydrocarbon receptor; Pulmonary disease; Disease; Medicine; Aryl; Chemistry; Internal medicine; Biochemistry; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007438331,0.0002555562,0.0003389612,0.0000737326,0.0006176514,0.0000344025,0.000513505,0.00006526918,0.0003845421],"category_scores_gemma":[0.0005141357,0.0001252502,0.0003124891,0.0005572989,0.0005340465,0.0001705263,0.0002472754,0.0007303969,0.00001422288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006440787,"about_ca_system_score_gemma":0.002911031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002874786,"about_ca_topic_score_gemma":0.00005081233,"domain_scores_codex":[0.997044,0.0003845322,0.0007128026,0.0003032865,0.001118156,0.0004372831],"domain_scores_gemma":[0.9977362,0.0004152531,0.0004289226,0.0007119006,0.0005220912,0.0001855955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007220345,0.000616095,0.003733051,0.0002373421,0.0002746542,0.0001549734,0.004583903,0.0002647885,0.9643559,0.001679625,0.00005353896,0.02332404],"study_design_scores_gemma":[0.001553019,0.0001804546,0.2805804,0.0006289631,0.0006046754,0.0008886399,0.02032771,0.004492863,0.6790545,0.01109164,0.0002874285,0.0003097315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848661,0.008750447,0.003408966,0.001409861,0.0003636567,0.0006746514,0.00007581367,0.00001576271,0.0004346951],"genre_scores_gemma":[0.9979895,0.0003926637,0.000927056,0.00007329408,0.0002437829,0.00004777173,0.00004832893,0.00003483992,0.0002427159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2853015,"threshold_uncertainty_score":0.5164043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02850709173125679,"score_gpt":0.2813350911794806,"score_spread":0.2528279994482238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}