{"id":"W3132688716","doi":"10.1096/fj.202002350r","title":"Aryl hydrocarbon receptor deficiency causes the development of chronic obstructive pulmonary disease through the integration of multiple pathogenic mechanisms","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Klox Technologies (Canada); St. Joseph’s Healthcare Hamilton; McMaster University; St. Paul's Hospital; CIS Scientific; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; McGill University; University of British Columbia Hospital; McGill University Health Centre","funders":"Institute of Circulatory and Respiratory Health; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; Canada Foundation for Innovation; National Institutes of Health; Canada Research Chairs; Fonds de Recherche du Québec - Santé; Université Laval; Michael Smith Health Research BC; Government of Canada; Canadian Institutes of Health Research; Teva Pharmaceutical Industries; McGill University Health Centre; Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Aryl hydrocarbon receptor; Pulmonary disease; Disease; Medicine; Aryl; Chemistry; Internal medicine; Biochemistry; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452247,0.0004289367,0.0003260613,0.0003514289,0.0001745517,0.0001988353,0.0001403905,0.0003717278,0.001980461],"category_scores_gemma":[0.0001362698,0.0001501806,0.000231438,0.0001885095,0.000327893,0.0001546257,0.000288473,0.0005260417,0.0003877697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001647271,"about_ca_system_score_gemma":0.0002146218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004428601,"about_ca_topic_score_gemma":0.0006085635,"domain_scores_codex":[0.9998204,0.00003765286,0.00002139266,0.00003794745,0.00005047738,0.00003212294],"domain_scores_gemma":[0.999846,0.00001686982,0.00004532225,0.00001375113,0.00001254766,0.00006557487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004671014,0.0001311892,0.002731215,0.0001070706,0.00002538693,0.0007663732,0.00001853437,0.00004369358,0.9905613,0.0002906968,0.0001632552,0.004694166],"study_design_scores_gemma":[0.0003324368,0.003672476,0.1723673,0.00009122557,0.0002761514,0.02080309,0.0002616495,0.001969401,0.7767678,0.001027374,0.02238315,0.00004795587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925261,0.002920323,0.00225469,0.0003013629,0.00007101425,0.00004137357,0.0004816843,0.0001192999,0.001284223],"genre_scores_gemma":[0.9927092,0.002189609,0.001649547,0.00009190255,0.00003182671,0.00003114696,0.0004884519,0.00001937832,0.002788905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001980461,"threshold_uncertainty_score":0.006625295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02850709173125679,"score_gpt":0.2813350911794806,"score_spread":0.2528279994482238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}