{"id":"W3132797257","doi":"10.1158/1538-7445.sabcs20-ps8-02","title":"Abstract PS8-02: Influence of a breast cancer polygenic risk score on adherence to preventive endocrine therapy in high risk women at 1 and 2 year follow-up: The genetic risk estimate (GENRE) trial","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba","funders":"","keywords":"Medicine; Breast cancer; Framingham Risk Score; Risk assessment; Single-nucleotide polymorphism; Absolute risk reduction; Family history; Genetic testing; Demography; Internal medicine; Gynecology; Confidence interval; Cancer; Genetics; Genotype; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002489131,0.0006772637,0.0008813223,0.0002243306,0.0002700674,0.0007441328,0.0005311205,0.0009015653,0.004491993],"category_scores_gemma":[0.004741076,0.000223259,0.001343172,0.0003644349,0.000327348,0.0005681092,0.0004289547,0.002074889,0.0004479107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003042238,"about_ca_system_score_gemma":0.0005153902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001711503,"about_ca_topic_score_gemma":0.001447802,"domain_scores_codex":[0.9988569,0.0007794747,0.00007100823,0.0001618189,0.00008091433,0.00004992681],"domain_scores_gemma":[0.9983324,0.0005929327,0.0004261511,0.0002551379,0.0000984026,0.0002949547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8805423,0.005605539,0.05281895,0.001055435,0.005670139,0.00009230767,0.0001337039,0.001056916,0.001334578,0.0003529019,0.004027398,0.04730985],"study_design_scores_gemma":[0.5817165,0.1735428,0.2193838,0.0003173667,0.01284467,0.0001857983,0.0001591389,0.004585298,0.000869145,0.001410719,0.004906327,0.0000784266],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901299,0.002832494,0.0004238376,0.0008697301,0.0001912333,0.0007695802,0.002055085,0.00005773062,0.002670439],"genre_scores_gemma":[0.9921651,0.001023824,0.0007748998,0.000582323,0.000320039,0.000828278,0.002184825,0.00001377473,0.002106915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004491993,"threshold_uncertainty_score":0.01502717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03110399006129249,"score_gpt":0.3758865257716794,"score_spread":0.3447825357103869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}