{"id":"W3132803064","doi":"10.1002/art.41716","title":"Withdrawing Ixekizumab in Patients With Psoriatic Arthritis Who Achieved Minimal Disease Activity: Results From a Randomized, Double‐Blind Withdrawal Study","year":2021,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Memorial University of Newfoundland","funders":"National Institute for Health and Care Research; Eli Lilly and Company","keywords":"Ixekizumab; Psoriatic arthritis; Medicine; Double blind; Arthritis; Randomized controlled trial; Dermatology; Internal medicine; Pharmacology; Placebo; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003114366,0.0008934443,0.00283066,0.0002540917,0.0003610133,0.000555856,0.0004854403,0.001047372,0.00247942],"category_scores_gemma":[0.002805786,0.0003919818,0.001895842,0.0002553129,0.0008151061,0.0006614663,0.0002735143,0.001594919,0.0003672837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003752582,"about_ca_system_score_gemma":0.0009059547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002968713,"about_ca_topic_score_gemma":0.000642315,"domain_scores_codex":[0.9987069,0.0007735331,0.0001343592,0.0001395482,0.0001326341,0.0001129154],"domain_scores_gemma":[0.9983052,0.0006245276,0.0004785123,0.0001544289,0.00009524104,0.0003421245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9241101,0.01551724,0.00369713,0.0009662554,0.001394064,0.00008996562,0.0001103599,0.0002417583,0.008396489,0.00004730327,0.0005385316,0.04489086],"study_design_scores_gemma":[0.8082533,0.1823024,0.007352586,0.00003827929,0.0006144651,0.0000845137,0.00002295662,0.0002584334,0.0005924754,0.00005733932,0.0004088942,0.00001437471],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951482,0.002748494,0.0003241267,0.0001783878,0.0001095341,0.001016101,0.0001896715,0.00002734925,0.0002581656],"genre_scores_gemma":[0.994803,0.001698729,0.0007889808,0.0004938357,0.0002741042,0.001146531,0.0003698611,0.000008578512,0.0004164766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003114366,"threshold_uncertainty_score":0.01647055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065447308516283,"score_gpt":0.2479202783434953,"score_spread":0.2372658052583325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}