{"id":"W3132804690","doi":"10.3390/ijms22052271","title":"Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis","year":2021,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"","keywords":"Chronic wasting disease; Biology; Pathogenesis; Allele; Prion protein; Genetics; Transgene; Epitope; Disease; Virology; Gene; Immunology; Scrapie; Antibody; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005794333,0.0009452042,0.001265957,0.002493654,0.000260966,0.0009875854,0.0009272834,0.001309796,0.002455399],"category_scores_gemma":[0.0007575719,0.0002722795,0.0003646392,0.002242726,0.000536964,0.001345921,0.000686879,0.001753326,0.001763492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006025085,"about_ca_system_score_gemma":0.000895474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136806,"about_ca_topic_score_gemma":0.001400791,"domain_scores_codex":[0.9998618,0.00002305811,0.00002107943,0.00003295361,0.00004726725,0.00001373809],"domain_scores_gemma":[0.9996837,0.0001409062,0.00004177185,0.000008684468,0.00008556408,0.00003926034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001092249,0.00006571464,0.0002728493,0.01163265,0.00006050833,0.000236396,0.00006737676,0.0002918853,0.001330884,0.002778579,0.02179617,0.9613578],"study_design_scores_gemma":[0.00002357301,0.0001313981,0.001562885,0.004687884,0.0001273627,0.00223483,0.00006307726,0.00009826099,0.0004639195,0.002280091,0.9883025,0.00002423704],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001028499,0.9989035,0.00007468495,0.0001954147,0.0001291477,0.000002862502,0.00001190036,0.00000522404,0.0005743776],"genre_scores_gemma":[0.0005442523,0.9987221,0.0001204246,0.0001177414,0.0001130837,0.000004416096,0.00002330407,9.902742e-7,0.000353655],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002493654,"threshold_uncertainty_score":0.008214176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02278978180709112,"score_gpt":0.3250580416118103,"score_spread":0.3022682598047192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}