{"id":"W3132915896","doi":"10.3390/cancers13040831","title":"p38 MAPK Inhibition Mitigates Hypoxia-Induced AR Signaling in Castration-Resistant Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Terry Fox Research Institute; Prostate Cancer Canada","keywords":"Hsp27; Prostate cancer; Cancer research; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Androgen receptor; Heat shock protein; Kinase; Biology; Internal medicine; Chemistry; Medicine; Cell biology; Hsp70; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000146604,0.0007152655,0.0003283366,0.0002851594,0.0002325431,0.0001991858,0.0003834811,0.0001945343,0.00252428],"category_scores_gemma":[0.0000935423,0.0001494155,0.0004303374,0.0001759678,0.000200635,0.0001758627,0.0002159412,0.0009287272,0.0003758612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003158621,"about_ca_system_score_gemma":0.0005082972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009355841,"about_ca_topic_score_gemma":0.001973533,"domain_scores_codex":[0.9998806,0.00001367193,0.000007671076,0.00001763507,0.00003127542,0.00004924999],"domain_scores_gemma":[0.999945,0.000004813083,0.00001461576,0.000004091758,0.000008114664,0.00002323881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001314403,0.0007339251,0.0003284812,0.0003122375,0.00003522578,0.00009395827,0.00003561197,0.000533907,0.9865129,0.0001190568,0.0008285689,0.009151641],"study_design_scores_gemma":[0.000418028,0.00894354,0.01002153,0.00003736624,0.0001147306,0.0006673595,0.0001005126,0.004421067,0.9663162,0.0001670213,0.008771978,0.00002075999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906902,0.004096654,0.001820346,0.0003306577,0.0001337421,0.00009382894,0.0006152141,0.0003390723,0.00188031],"genre_scores_gemma":[0.9935105,0.001933268,0.001253553,0.00007211135,0.0000257408,0.0001146743,0.0006912526,0.0000232203,0.002375618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00252428,"threshold_uncertainty_score":0.008444607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03942220695797415,"score_gpt":0.324554701260556,"score_spread":0.2851324943025818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}