{"id":"W3132915896","doi":"10.3390/cancers13040831","title":"p38 MAPK Inhibition Mitigates Hypoxia-Induced AR Signaling in Castration-Resistant Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Terry Fox Research Institute; Prostate Cancer Canada","keywords":"Hsp27; Prostate cancer; Cancer research; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Androgen receptor; Heat shock protein; Kinase; Biology; Internal medicine; Chemistry; Medicine; Cell biology; Hsp70; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278734,0.0001728831,0.0002724138,0.0001291111,0.00009532071,0.00004589348,0.0000378307,0.00008624569,0.0003976199],"category_scores_gemma":[0.00004390316,0.0001547079,0.00007565891,0.0005240369,0.00007258003,0.0001370151,0.00002293365,0.0002558221,0.00001834069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002545037,"about_ca_system_score_gemma":0.00316269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001476504,"about_ca_topic_score_gemma":0.001497532,"domain_scores_codex":[0.9985109,0.00005087554,0.0002831082,0.0003954121,0.0003280222,0.0004317041],"domain_scores_gemma":[0.9992996,0.00004064132,0.00006523631,0.0001897671,0.0002263473,0.0001784435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005128551,0.00003981927,0.006151021,0.0002254516,0.00008218227,0.001051498,0.001006757,0.000402912,0.9863223,0.00005459974,0.0006525679,0.003497983],"study_design_scores_gemma":[0.003973613,0.0002080231,0.01246595,0.001000804,0.00006232915,0.00002197224,0.001776271,0.0001976358,0.9783103,0.0002189517,0.001539161,0.0002250035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908578,0.004426721,0.000001748033,0.002409601,0.0002192229,0.0005214101,0.00006568855,0.00004293123,0.001454909],"genre_scores_gemma":[0.9954189,0.001210619,0.0001599824,0.0003749651,0.000186683,0.0002960366,0.0001703507,0.00003014277,0.002152286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008012071,"threshold_uncertainty_score":0.6655183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03942220695797415,"score_gpt":0.324554701260556,"score_spread":0.2851324943025818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}