{"id":"W3132940432","doi":"10.1016/j.ecoenv.2021.112041","title":"Combined cytotoxicity of polystyrene nanoplastics and phthalate esters on human lung epithelial A549 cells and its mechanism","year":2021,"lang":"en","type":"article","venue":"Ecotoxicology and Environmental Safety","topic":"Microplastics and Plastic Pollution","field":"Environmental Science","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Higher Education Discipline Innovation Project; State Administration of Foreign Experts Affairs; Baylor University; Chinese Academy of Sciences; Canada Research Chairs; Ministry of Education of the People's Republic of China; National Natural Science Foundation of China","keywords":"Phthalate; Chemistry; Toxicity; Dibutyl phthalate; Bioavailability; Diethyl phthalate; Cytotoxicity; A549 cell; Inhalation; Environmental chemistry; Pharmacology; Viability assay; Oxidative stress; Human lung; Dimethyl phthalate; In vitro; Biochemistry; Cell culture; Organic chemistry; Biology; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002276935,0.0005104807,0.0003607986,0.0003219064,0.000237597,0.0002408485,0.0002016828,0.0005277075,0.0009173978],"category_scores_gemma":[0.0001567411,0.0002020165,0.0006347331,0.000242289,0.0002357968,0.0003181784,0.0003291144,0.0003101696,0.0003391157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001947119,"about_ca_system_score_gemma":0.0002164794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009833397,"about_ca_topic_score_gemma":0.001015302,"domain_scores_codex":[0.9996018,0.00008501278,0.00005491843,0.00006864823,0.0001359284,0.00005368319],"domain_scores_gemma":[0.9998497,0.00003126115,0.0000398236,0.00001957811,0.00004523839,0.00001431699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001700927,0.00005035594,0.001321396,0.0002673279,0.00003764916,0.0003643608,0.00005326185,0.0002245052,0.9945455,0.00008331049,0.0000602469,0.002821952],"study_design_scores_gemma":[0.00000835205,0.0008368423,0.009817537,0.00001949272,0.00005111945,0.0006982251,0.00009788774,0.0008296781,0.9859465,0.00007233073,0.001611628,0.00001046335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769982,0.0139244,0.005017576,0.0002416157,0.00009071102,0.00006942226,0.0005421949,0.00003968613,0.003076129],"genre_scores_gemma":[0.9891303,0.005725703,0.001568939,0.0001268785,0.00002866085,0.00008529713,0.0003665669,0.000005936507,0.002961734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009833397,"threshold_uncertainty_score":0.003069043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0072199915101689,"score_gpt":0.2027700926707046,"score_spread":0.1955501011605358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}