{"id":"W3132974468","doi":"10.1016/j.jmb.2021.166880","title":"SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function","year":2021,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Health Network; University of Toronto; Canada Research Chairs; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Garron Family Cancer Centre; Canadian Institutes of Health Research; Hospital for Sick Children; Cancer Research Society; American Brain Tumor Association","keywords":"Ubiquitin ligase; Signal transducing adaptor protein; SH2 domain; Ubiquitin; Cell biology; Chemistry; Tyrosine kinase; DNA ligase; Receptor tyrosine kinase; Biochemistry; Biology; Signal transduction; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733338,0.0003394769,0.0002617413,0.0002028064,0.0002387014,0.0003567124,0.0005009553,0.0004438118,0.002914081],"category_scores_gemma":[0.0001398659,0.0002007238,0.0002968699,0.0002026306,0.000296423,0.000151483,0.0002911674,0.000925429,0.0007419388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009365531,"about_ca_system_score_gemma":0.0004585893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002433661,"about_ca_topic_score_gemma":0.002392388,"domain_scores_codex":[0.9997051,0.00004272707,0.00003384383,0.00004422608,0.00007628068,0.00009774934],"domain_scores_gemma":[0.9998025,0.00003754225,0.00003993761,0.00002565918,0.00001226952,0.0000821092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001953733,0.0001003478,0.0001106377,0.00001978087,0.000009525007,0.00009146174,0.00000966733,0.0001828446,0.9987061,0.0001425647,0.00009560058,0.0003361626],"study_design_scores_gemma":[0.00007551134,0.0001949209,0.003247258,0.000006117658,0.000008644,0.0002599026,0.00003158462,0.003676348,0.9903674,0.00006154335,0.002061348,0.000009461778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967878,0.0003849581,0.0009075166,0.0001282923,0.00003400928,0.00001979099,0.000541129,0.0000912107,0.001105416],"genre_scores_gemma":[0.9977098,0.00009616985,0.0005197152,0.00005724339,0.000003838771,0.00001783728,0.0004333123,0.00001883799,0.001143325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002914081,"threshold_uncertainty_score":0.009748518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01251914418792888,"score_gpt":0.2763826396106209,"score_spread":0.2638634954226921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}