{"id":"W3133020115","doi":"10.1016/j.bpj.2020.11.1482","title":"Shape and Sedimentation Coefficients of Supercoiled DNA Minicircles","year":2021,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Lethbridge","funders":"","keywords":"Minicircle; DNA supercoil; Writhe; Persistence length; Physics; Brownian dynamics; Circular DNA; Geometry; Twist; Mathematics; DNA; Chemistry; Brownian motion; Molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002934294,0.0002437631,0.000181155,0.000600057,0.0002480933,0.0006673457,0.0004114706,0.0003234584,0.000856668],"category_scores_gemma":[0.001785151,0.0002423042,0.0001613467,0.0003799704,0.0003055388,0.0003583794,0.0001552103,0.0007120286,0.0003632919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000529965,"about_ca_system_score_gemma":0.0002765107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001298753,"about_ca_topic_score_gemma":0.0006312766,"domain_scores_codex":[0.9998189,0.0000249382,0.00001116885,0.00004100541,0.00006720229,0.00003680379],"domain_scores_gemma":[0.9986123,0.0004207808,0.0002586399,0.0000994349,0.0003567682,0.0002520207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005178098,0.00003845556,0.0017759,0.00002120041,0.00001108244,0.00003749194,0.000275037,0.0008149248,0.9918942,0.001031435,0.0002468808,0.003335544],"study_design_scores_gemma":[0.00002786676,0.0001823441,0.02411591,0.00001168077,0.00001572632,0.0001374489,0.0001517479,0.009042393,0.9642539,0.0004608947,0.001561939,0.00003817436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953406,0.0004581614,0.002532739,0.00005893233,0.00002271808,0.00001081571,0.0003019858,0.00004612019,0.00122792],"genre_scores_gemma":[0.9958526,0.0001990585,0.001057873,0.00002946349,0.000007569758,0.00001932648,0.001071123,0.00007178001,0.001691267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298753,"threshold_uncertainty_score":0.003845155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207657468163203,"score_gpt":0.2598672929710136,"score_spread":0.2477907182893815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}