{"id":"W3133061598","doi":"10.1007/s40744-021-00287-y","title":"Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis","year":2021,"lang":"en","type":"article","venue":"Rheumatology and Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"ReumaNederland; ZonMw; Dutch Arthritis Society; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit Leiden; Arthritis Society","keywords":"Chondrocyte; Cartilage; Downregulation and upregulation; Osteoarthritis; Catabolism; Muscle hypertrophy; Anabolism; Matrix Metalloproteinase 3; Chemistry; Cell biology; Endocrinology; Internal medicine; Medicine; Matrix metalloproteinase; Pathology; Biology; Anatomy; Biochemistry; Gene; Metabolism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012211,0.0006100958,0.0005875662,0.0005140692,0.0002576099,0.000670716,0.0003980768,0.0008559794,0.001631471],"category_scores_gemma":[0.0003185579,0.0002611221,0.0005123072,0.0003932257,0.0005016551,0.0003652027,0.0004995865,0.001088452,0.0008122594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002640935,"about_ca_system_score_gemma":0.0004398004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006610324,"about_ca_topic_score_gemma":0.002114945,"domain_scores_codex":[0.9993092,0.0001641431,0.0000654401,0.00009512784,0.0002969578,0.00006914621],"domain_scores_gemma":[0.9995833,0.00007574925,0.0001137514,0.00007056217,0.00009420918,0.00006237812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001170601,0.00005029414,0.0003557596,0.0003616074,0.00001495834,0.0000953147,0.00003640894,0.0001606905,0.9945382,0.0001379668,0.0001618546,0.003969915],"study_design_scores_gemma":[0.00009233893,0.003206076,0.01168116,0.0003044523,0.0001689361,0.001289436,0.000306232,0.002197366,0.9548759,0.0006216978,0.02520435,0.00005204558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7373352,0.1247491,0.118889,0.001721716,0.0009734015,0.0008078445,0.004957552,0.0005534065,0.01001281],"genre_scores_gemma":[0.9115705,0.03543088,0.04182829,0.0004422732,0.0002110171,0.0008635856,0.003146968,0.0000908862,0.006415583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001631471,"threshold_uncertainty_score":0.005457819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03347883714411846,"score_gpt":0.2733837220021514,"score_spread":0.2399048848580329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}