{"id":"W3133100812","doi":"10.1073/pnas.2016897118","title":"Nile Red fluorescence spectroscopy reports early physicochemical changes in myelin with high sensitivity","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Institute of Neurosciences, Mental Health and Addiction; Canadian Institutes of Health Research; Cumming School of Medicine, University of Calgary; Stichting MS Research; Canada Foundation for Innovation; Canada Research Chairs; Koninklijke Nederlandse Akademie van Wetenschappen; Multiple Sclerosis Society of Canada; Government of Canada","keywords":"Nile red; Fluorescence; Fluorescence spectroscopy; Spectroscopy; Sensitivity (control systems); West Nile virus; Chemistry; Biophysics; Biology; Optics; Physics; Virology; Engineering; Astronomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001119762,0.00009080898,0.0002522732,0.0001110638,0.00009002264,0.00001513063,0.0001396993,0.00005151665,0.00001085879],"category_scores_gemma":[0.001973205,0.00005701391,0.0000418076,0.001033347,0.0009346086,0.0001732959,0.0001691114,0.0002517615,3.909961e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006425437,"about_ca_system_score_gemma":0.0001057194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003996937,"about_ca_topic_score_gemma":0.000002656432,"domain_scores_codex":[0.997569,0.000010426,0.0002283423,0.0003417738,0.001644253,0.0002061616],"domain_scores_gemma":[0.9989861,0.00014433,0.0002342753,0.00001517887,0.0005745374,0.00004561438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000513749,0.00008362085,0.08404543,0.00007635856,0.00001353523,5.684822e-7,0.0001425064,0.000004459298,0.9146346,0.0004941788,0.0003318854,0.000121504],"study_design_scores_gemma":[0.0001508428,0.00004408409,0.4368525,0.0002326007,0.000005116763,0.00002189979,0.00008402052,0.0001225599,0.5615685,0.0008743622,0.00000980638,0.00003370352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842505,0.00004737523,2.66464e-7,0.01418141,0.000008416601,0.0001960562,0.000005809687,0.00000923287,0.001300858],"genre_scores_gemma":[0.9951061,0.00007459398,0.004495111,0.0001263561,0.0001035495,0.00001141506,2.812554e-7,0.000003976075,0.00007860246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3530661,"threshold_uncertainty_score":0.3443604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04511741135172544,"score_gpt":0.3259995058664779,"score_spread":0.2808820945147525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}