{"id":"W3133165156","doi":"10.3389/fimmu.2021.647070","title":"Administration of GDF3 Into Septic Mice Improves Survival via Enhancing LXRα-Mediated Macrophage Phagocytosis","year":2021,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute","funders":"National Institute of General Medical Sciences; National Institutes of Health; American Heart Association","keywords":"Phagocytosis; Macrophage; Liver X receptor; Inflammation; Innate immune system; Sepsis; Biology; Immunology; Downregulation and upregulation; Cytokine; Microbiology; Immune system; Cancer research; Cell biology; In vitro; Nuclear receptor; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001876349,0.0003736481,0.0005480826,0.0003932836,0.000187655,0.0003235583,0.0001992853,0.0005594357,0.00167955],"category_scores_gemma":[0.0001108938,0.0001294021,0.000497599,0.0001919173,0.0003508566,0.000187902,0.0001797779,0.001201868,0.0003814833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003377979,"about_ca_system_score_gemma":0.0005005789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008549999,"about_ca_topic_score_gemma":0.001603046,"domain_scores_codex":[0.99984,0.00001759461,0.00001282246,0.0000283188,0.00003342595,0.000067783],"domain_scores_gemma":[0.9999279,0.000005339866,0.00002122559,0.000005698326,0.000008681208,0.00003110259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001808367,0.000162146,0.0003775145,0.0002039698,0.0000176888,0.00008446808,0.00002988897,0.000133796,0.9915173,0.0001521278,0.0004420684,0.005070737],"study_design_scores_gemma":[0.0003930707,0.002568841,0.00792709,0.00005106605,0.00008906842,0.000386817,0.0001170007,0.0009667866,0.9759052,0.0002742595,0.0112994,0.00002135625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827556,0.005576544,0.004773006,0.0008563019,0.0002132652,0.00009713967,0.002645935,0.0006250865,0.002457177],"genre_scores_gemma":[0.9875919,0.002473141,0.003472636,0.0004192358,0.00003906938,0.0001680065,0.002077136,0.00007382611,0.00368505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167955,"threshold_uncertainty_score":0.005618632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005274347784688143,"score_gpt":0.225602230671902,"score_spread":0.2203278828872139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}