{"id":"W3133183473","doi":"10.1038/s41598-021-90049-1","title":"Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Institute of Cancer Research; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"KRAS; Organoid; MEK inhibitor; Trametinib; Pancreatic cancer; Cancer research; MAPK/ERK pathway; Adenocarcinoma; Medicine; Phenotype; Cancer; Biology; Internal medicine; Gene; Colorectal cancer; Kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005572596,0.0003189319,0.0003213149,0.0003649935,0.000175006,0.0003471,0.0002742527,0.0003269297,0.002428601],"category_scores_gemma":[0.0002333627,0.0001861507,0.0003605481,0.0003803861,0.0001946672,0.000288285,0.0002558681,0.0008360855,0.000660995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002299393,"about_ca_system_score_gemma":0.0002491575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005857741,"about_ca_topic_score_gemma":0.0009509017,"domain_scores_codex":[0.999727,0.0000611761,0.00004500323,0.00005859998,0.00006627183,0.00004200247],"domain_scores_gemma":[0.9996523,0.00008843074,0.00004363085,0.0001066537,0.00003302116,0.00007599862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002378584,0.001013669,0.007463241,0.0002448177,0.00004708504,0.0009426249,0.0003014826,0.002141431,0.97677,0.001482807,0.0008844621,0.006329813],"study_design_scores_gemma":[0.0003127269,0.01236175,0.03409233,0.00004541828,0.0001141121,0.0074031,0.0004969459,0.009882503,0.9159849,0.0003831511,0.01888465,0.0000384604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861741,0.0006294001,0.006716309,0.00006257399,0.00004910838,0.0003088951,0.003550995,0.00008686254,0.002421809],"genre_scores_gemma":[0.9807824,0.0007665782,0.008027827,0.00004682293,0.000009109003,0.0003694301,0.006697366,0.00002955111,0.003270966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002428601,"threshold_uncertainty_score":0.008124471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02113759560855025,"score_gpt":0.2788589508716365,"score_spread":0.2577213552630862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}