{"id":"W3133229959","doi":"10.1056/nejmoa2024850","title":"Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma","year":2021,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2424,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Bristol-Myers Squibb","keywords":"Chimeric antigen receptor; Refractory (planetary science); Multiple myeloma; Antigen; Cancer research; Medicine; Receptor; T cell; Internal medicine; Immunology; Biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006921369,0.0003559992,0.0006796346,0.0002983803,0.0002766763,0.0002232356,0.0003232839,0.0003326947,0.0005619162],"category_scores_gemma":[0.0006975629,0.0001084182,0.0003143064,0.0003640058,0.0002635248,0.0001726927,0.0001929328,0.000433472,0.0001896445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005873148,"about_ca_system_score_gemma":0.0003430394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113376,"about_ca_topic_score_gemma":0.00201591,"domain_scores_codex":[0.9997472,0.0000967649,0.00002291142,0.00003316522,0.00005785319,0.0000422034],"domain_scores_gemma":[0.99975,0.00007003549,0.00007089023,0.00001790296,0.00001623317,0.00007501467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.03665624,0.002548259,0.2520178,0.001839087,0.00125269,0.02323496,0.0009231092,0.006880775,0.07311712,0.0005091048,0.009560953,0.59146],"study_design_scores_gemma":[0.01356595,0.07855368,0.7140051,0.0003965418,0.001403107,0.1130639,0.000385105,0.01347554,0.03512811,0.0009876608,0.02895876,0.00007673557],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874155,0.01064344,0.0004066946,0.0002785144,0.0000321496,0.00005368596,0.00008308473,0.00004285483,0.001044108],"genre_scores_gemma":[0.996877,0.002242766,0.0002506358,0.000151026,0.00006348213,0.00002168339,0.0001521307,0.000006244292,0.0002350445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00113376,"threshold_uncertainty_score":0.004261255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03150045003787461,"score_gpt":0.317176045044978,"score_spread":0.2856755950071034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}