{"id":"W3133280714","doi":"10.1016/j.joca.2021.01.008","title":"Increased IL-6 receptor expression and signaling in ageing cartilage can be explained by loss of TGF-β-mediated IL-6 receptor suppression","year":2021,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Arthritis Society; ReumaNederland; Dutch Arthritis Society","keywords":"Ageing; Cartilage; Receptor; Internal medicine; Endocrinology; Signal transduction; Transforming growth factor; STAT3; Gene expression; Western blot; Interleukin; Medicine; Andrology; Chemistry; Biology; Cell biology; Cytokine; Anatomy; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003238308,0.0004159309,0.0008575276,0.000172753,0.0001828715,0.00006766125,0.00007649813,0.0003198285,0.000485829],"category_scores_gemma":[0.0002346898,0.0004071057,0.0001270621,0.0003219745,0.0001710777,0.000241567,0.0001511177,0.0002905313,0.000006271418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006346295,"about_ca_system_score_gemma":0.0001240029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005683171,"about_ca_topic_score_gemma":0.0003529938,"domain_scores_codex":[0.9972347,0.0002688635,0.0006946184,0.0007453776,0.0004729553,0.0005834997],"domain_scores_gemma":[0.9985845,0.0001938541,0.0001988108,0.0003914222,0.0001585293,0.0004728575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004623981,0.0001812369,0.00421103,0.0001669947,0.000005031678,0.0008057719,0.001422838,3.17285e-7,0.9857143,0.00002238237,0.0007727895,0.006234947],"study_design_scores_gemma":[0.01034372,0.001471692,0.0001125171,0.002046757,0.00006830343,0.0001071327,0.002509564,0.000003453772,0.976821,0.0000276467,0.006125828,0.0003623913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902362,0.006940035,0.000003673759,0.0004862153,0.0002414727,0.0006391464,0.0009676563,0.00007519243,0.0004104396],"genre_scores_gemma":[0.9954846,0.001396075,0.000616062,0.0002816475,0.0001018619,0.0001042158,0.001390076,0.0000699011,0.0005555691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009881319,"threshold_uncertainty_score":0.9998381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008567434643518064,"score_gpt":0.2222053866290652,"score_spread":0.2136379519855471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}