{"id":"W3133283630","doi":"10.1038/s41388-021-01680-1","title":"HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner","year":2021,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia Hospital; Occupational Cancer Research Centre; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Österreichischen Akademie der Wissenschaften; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation; National University of Singapore; Government of Canada; Conquer Cancer Foundation; University of Toronto; Michael Smith Health Research BC","keywords":"Biology; Ubiquitin ligase; Ubiquitin; RAC1; Cell biology; Proteolysis; Lewis lung carcinoma; Cancer research; Molecular biology; Metastasis; Biochemistry; Cancer; Signal transduction; Genetics; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001251812,0.0002253403,0.0001620602,0.0001684946,0.0001573842,0.0001667253,0.0002006034,0.0001795032,0.001279008],"category_scores_gemma":[0.00009500571,0.0001007607,0.0001439558,0.000100384,0.0002409625,0.000114437,0.0001341041,0.000450298,0.0002609389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002760439,"about_ca_system_score_gemma":0.0001851556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004877886,"about_ca_topic_score_gemma":0.0006545821,"domain_scores_codex":[0.9998994,0.00002065346,0.000007125959,0.00001837896,0.00002392126,0.00003044859],"domain_scores_gemma":[0.9998887,0.00001921658,0.00003583715,0.00001623831,0.00001367519,0.00002632651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001283934,0.00004097215,0.00007441057,0.00002142875,0.0000037069,0.00001862936,0.000004917096,0.00007079164,0.9987299,0.00009924678,0.00003982702,0.0007678016],"study_design_scores_gemma":[0.00001047554,0.0001697005,0.001099242,0.000002015653,0.0000045681,0.0001099107,0.00000661802,0.0007168406,0.9964656,0.00002336304,0.001390497,0.000001327565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951997,0.0008856727,0.0022103,0.0001780043,0.00002205633,0.00002172351,0.000243817,0.00009214735,0.001146499],"genre_scores_gemma":[0.9947913,0.0005858799,0.001510202,0.00004862556,0.000008455489,0.00003072135,0.0003739234,0.00002219488,0.002628725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001279008,"threshold_uncertainty_score":0.00427866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02338653388478008,"score_gpt":0.2925696258377786,"score_spread":0.2691830919529985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}