{"id":"W3133283630","doi":"10.1038/s41388-021-01680-1","title":"HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner","year":2021,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia Hospital; Occupational Cancer Research Centre; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Österreichischen Akademie der Wissenschaften; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation; National University of Singapore; Government of Canada; Conquer Cancer Foundation; University of Toronto; Michael Smith Health Research BC","keywords":"Biology; Ubiquitin ligase; Ubiquitin; RAC1; Cell biology; Proteolysis; Lewis lung carcinoma; Cancer research; Molecular biology; Metastasis; Biochemistry; Cancer; Signal transduction; Genetics; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399463,0.0001493205,0.0001718339,0.00004682119,0.00004515174,0.00002765907,0.000111779,0.0001859397,0.0001787797],"category_scores_gemma":[0.00004416076,0.0001572609,0.00009537389,0.000133227,0.00002499887,0.00000471355,0.0001148061,0.00009356616,0.00002649957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003634258,"about_ca_system_score_gemma":0.0001887118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000685401,"about_ca_topic_score_gemma":0.001222732,"domain_scores_codex":[0.9988939,0.00006107433,0.0002133259,0.0004091009,0.0001577386,0.0002648376],"domain_scores_gemma":[0.9993842,0.000008236854,0.0000584137,0.0003774262,0.00008656113,0.0000851366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005767333,0.0001020618,0.0006115159,0.000007498899,0.00003897008,0.0000123357,0.00004319305,0.001218359,0.9825014,0.0000744858,0.00299812,0.01233431],"study_design_scores_gemma":[0.001565392,0.00004274352,0.007220961,0.00001323014,0.00003721947,0.0000583788,0.0001130711,0.00009299781,0.6064745,0.0002473296,0.3838568,0.0002773598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847219,0.009599818,0.001224852,0.0003771331,0.001055235,0.0001326322,0.00002043088,0.00001247242,0.002855518],"genre_scores_gemma":[0.9854469,0.00142092,0.0008955302,0.0007960105,0.001465755,0.00002721893,0.0002202221,0.00002920927,0.009698261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3808587,"threshold_uncertainty_score":0.6412914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02338653388478008,"score_gpt":0.2925696258377786,"score_spread":0.2691830919529985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}