{"id":"W3133438047","doi":"10.1038/s41467-021-21287-0","title":"Polygenic hazard score is associated with prostate cancer in multi-ethnic populations","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic and phenotypic traits in livestock","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Alberta; Princess Margaret Cancer Centre; Institut National de la Recherche Scientifique; University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; Norges Forskningsråd; Department of Health and Social Care; National Institute for Health and Care Research; NIHR Bristol Biomedical Research Centre; National Cancer Institute; U.S. Department of Health and Human Services; Cancer Research UK; U.S. Department of Defense","keywords":"Prostate cancer; Ethnic group; Hazard ratio; Demography; Medicine; Oncology; Biology; Cancer; Internal medicine; Confidence interval; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001785933,0.0002279287,0.0003799711,0.0005685621,0.000382297,0.0007895951,0.0003290843,0.0002984437,0.004099647],"category_scores_gemma":[0.004757633,0.0001489646,0.000853386,0.001414064,0.0002691964,0.0002809161,0.000653438,0.0004596584,0.0003031606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001795338,"about_ca_system_score_gemma":0.0002235502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007001869,"about_ca_topic_score_gemma":0.005673571,"domain_scores_codex":[0.9986995,0.0006938339,0.00005913995,0.0003359269,0.00009403213,0.0001174733],"domain_scores_gemma":[0.9960209,0.001628523,0.001146393,0.0007197158,0.0001926597,0.0002918433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001620221,0.00001782904,0.9943483,0.00001611491,0.0007110472,0.0000781807,0.0000464668,0.0005307498,0.0004514039,0.0001486687,0.0005861076,0.002903019],"study_design_scores_gemma":[0.00001029862,0.00004885858,0.9954556,0.000009206084,0.0001915222,0.0001812588,0.00006796461,0.00290468,0.0001380234,0.0004532152,0.0005308415,0.000008459683],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936242,0.0003516322,0.001653533,0.0002169335,0.00001614549,0.000005713893,0.003348913,0.0000328391,0.0007500426],"genre_scores_gemma":[0.9979337,0.00006172141,0.0003367868,0.00003888595,0.00001207637,0.000005942609,0.001410002,0.000006404514,0.0001945529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007001869,"threshold_uncertainty_score":0.01392221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04612998865746117,"score_gpt":0.3361740001680609,"score_spread":0.2900440115105997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}