{"id":"W3133482544","doi":"10.1101/2021.02.23.432522","title":"Combinatorial transcription factor profiles predict mature and functional human islet α and β cells","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center; Human Islet Research Network; National Institutes of Health; Vanderbilt University","keywords":"Islet; Biology; Transcription factor; Cell biology; Gene expression; Pancreatic islets; Secretion; Gene; Endocrinology; Insulin; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276325,0.0001598351,0.0002281094,0.0003159245,0.00008909121,0.0004243353,0.00007029474,0.0002003901,0.001325988],"category_scores_gemma":[0.0002793763,0.0001031427,0.0001604402,0.0002756032,0.00009193259,0.0001180551,0.00013882,0.0001785857,0.000631127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001217322,"about_ca_system_score_gemma":0.00007111218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005473553,"about_ca_topic_score_gemma":0.000725681,"domain_scores_codex":[0.9999254,0.000004663618,0.000005361539,0.00003644442,0.00001369037,0.00001447944],"domain_scores_gemma":[0.9998711,0.00003588023,0.00002524215,0.00001473086,0.00002489296,0.0000280682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000210759,0.000008537393,0.02162199,0.00002885038,0.0000132935,0.00004809918,0.0000509419,0.0003039335,0.9735744,0.00006394618,0.0001101396,0.003965094],"study_design_scores_gemma":[0.00002907857,0.0002044895,0.456867,0.00001605554,0.00009149589,0.001260629,0.0002319258,0.008680428,0.5275361,0.0004832448,0.004575432,0.00002410964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890578,0.0005591484,0.0074009,0.00002696887,0.000007595248,0.00001049742,0.002072169,0.0001066821,0.0007582251],"genre_scores_gemma":[0.9917946,0.0001822139,0.004638833,0.00003710655,0.000007215172,0.00001795107,0.002506725,0.00004396207,0.0007713716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325988,"threshold_uncertainty_score":0.004435897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482676145020183,"score_gpt":0.2124547381862831,"score_spread":0.1976279767360813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}