{"id":"W3133493210","doi":"10.2217/fon-2020-1274","title":"Molecular and Morphological Changes Induced by Ivosidenib Correlate with Efficacy in Mutant- <i>IDH1</i> Cholangiocarcinoma","year":2021,"lang":"en","type":"article","venue":"Future Oncology","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Agios Pharmaceuticals","keywords":"IDH1; Isocitrate dehydrogenase; Medicine; Cancer research; Intrahepatic Cholangiocarcinoma; Downregulation and upregulation; Mutant; Internal medicine; Oncology; Biology; Gene; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001114401,0.0002588691,0.0006470482,0.00009677939,0.0000649279,0.00001736891,0.000077789,0.0003371854,0.00007370312],"category_scores_gemma":[0.00005221866,0.0001972283,0.0000617372,0.0003618861,0.0001236738,0.00003709472,0.0001171502,0.0005726221,0.00001147548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001357437,"about_ca_system_score_gemma":0.0001737454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005709658,"about_ca_topic_score_gemma":0.0004553935,"domain_scores_codex":[0.9985026,0.0001209452,0.0002089823,0.0005578569,0.0001933011,0.0004163523],"domain_scores_gemma":[0.9992787,0.00009860549,0.00007528012,0.0002789981,0.00009286409,0.0001755859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001885091,0.001235858,0.1239881,0.0001381083,0.0004684309,0.03913347,0.002985081,0.00000197578,0.7944957,0.0004051476,0.01007779,0.0251852],"study_design_scores_gemma":[0.01600138,0.004124451,0.8501033,0.0001685318,0.0004214538,0.008219446,0.002441994,0.00001222504,0.04436689,0.00003448976,0.07352575,0.0005800976],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623083,0.01283937,0.00000735564,0.02001552,0.0002866399,0.0003385843,0.00001136343,0.00005290831,0.004139899],"genre_scores_gemma":[0.9930595,0.0005093362,0.0002488454,0.005568841,0.0003255523,0.00006110774,0.00005993805,0.00003067954,0.0001361699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7501288,"threshold_uncertainty_score":0.8042737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478920642627858,"score_gpt":0.2702181729730269,"score_spread":0.2554289665467483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}