{"id":"W3133493210","doi":"10.2217/fon-2020-1274","title":"Molecular and Morphological Changes Induced by Ivosidenib Correlate with Efficacy in Mutant- <i>IDH1</i> Cholangiocarcinoma","year":2021,"lang":"en","type":"article","venue":"Future Oncology","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Agios Pharmaceuticals","keywords":"IDH1; Isocitrate dehydrogenase; Medicine; Cancer research; Intrahepatic Cholangiocarcinoma; Downregulation and upregulation; Mutant; Internal medicine; Oncology; Biology; Gene; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001863057,0.0001076789,0.0001541092,0.0002476719,0.00009234175,0.0002116721,0.00008251297,0.0001645516,0.001777307],"category_scores_gemma":[0.0001648342,0.00008006326,0.0001328503,0.0001498555,0.0001551785,0.0001397272,0.00008125134,0.0003193524,0.0002244264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002936042,"about_ca_system_score_gemma":0.0001316284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004016999,"about_ca_topic_score_gemma":0.0005778738,"domain_scores_codex":[0.9999354,0.00001607359,0.000006267823,0.00001086369,0.0000144123,0.00001697799],"domain_scores_gemma":[0.999836,0.00003459379,0.00005473029,0.00001362021,0.00001734309,0.00004373436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006172073,0.0003010667,0.02460596,0.00009744208,0.00003788354,0.0002196025,0.00004712516,0.0001679045,0.954329,0.0001076004,0.0002748505,0.01363947],"study_design_scores_gemma":[0.0002872395,0.01026201,0.3359328,0.00002093191,0.0001249735,0.002237034,0.0001619208,0.0009058476,0.64665,0.0001151556,0.003289571,0.00001262461],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972166,0.0009794728,0.0002122165,0.00003158729,0.000005781303,0.0000230331,0.0002279029,0.00002076078,0.001282741],"genre_scores_gemma":[0.9986141,0.0002500353,0.0003070422,0.00001878204,0.000003698321,0.00002241258,0.0002845332,0.000006094494,0.0004933038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001777307,"threshold_uncertainty_score":0.005945742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478920642627858,"score_gpt":0.2702181729730269,"score_spread":0.2554289665467483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}