{"id":"W3133510375","doi":"10.1093/cvr/cvab065","title":"Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1","year":2021,"lang":"en","type":"letter","venue":"Cardiovascular Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Metformin; AMPK; Macrophage; Medicine; Diabetes mellitus; Endocrinology; Cell biology; Chemistry; Biology; Protein kinase A; Biochemistry; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001962308,0.0006050674,0.000954638,0.0004880509,0.001601505,0.001623076,0.0009114206,0.0152086,0.004212891],"category_scores_gemma":[0.007097225,0.000305328,0.000974501,0.0002828527,0.001483212,0.002316477,0.0007576127,0.01884492,0.003618462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001962047,"about_ca_system_score_gemma":0.001354502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001539463,"about_ca_topic_score_gemma":0.002308941,"domain_scores_codex":[0.9991745,0.0002670077,0.00008814547,0.0001038608,0.0002597865,0.0001066063],"domain_scores_gemma":[0.9979637,0.001216114,0.0001437336,0.0001060597,0.0002865969,0.0002838823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004833079,0.0001948019,0.001269667,0.0001667524,0.00005246928,0.007486055,0.0001266289,0.0001547279,0.002334074,0.008433764,0.9258823,0.05341547],"study_design_scores_gemma":[0.0008242226,0.0004261526,0.00312876,0.000454493,0.00009251001,0.008520955,0.0005557744,0.001128422,0.002342265,0.03230038,0.9501305,0.00009553893],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001287012,0.005251823,0.0001394503,0.9700992,0.02105699,0.00001211115,0.00004383074,0.00003167155,0.002077859],"genre_scores_gemma":[0.01842544,0.01097068,0.0005618674,0.8629265,0.09625651,0.00006071677,0.00005078284,0.00002637626,0.01072105],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0152086,"threshold_uncertainty_score":0.01423573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03484279349075336,"score_gpt":0.2914234663635707,"score_spread":0.2565806728728174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}