{"id":"W3133510375","doi":"10.1093/cvr/cvab065","title":"Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1","year":2021,"lang":"en","type":"letter","venue":"Cardiovascular Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Metformin; AMPK; Macrophage; Medicine; Diabetes mellitus; Endocrinology; Cell biology; Chemistry; Biology; Protein kinase A; Biochemistry; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002801253,0.0004179503,0.0007646621,0.000181082,0.0002438794,0.0001849718,0.0004543163,0.001548238,0.000139474],"category_scores_gemma":[0.0005258544,0.0004009741,0.00088056,0.0004004503,0.0003541821,0.000007645011,0.0004595497,0.002094494,0.00005468185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008482752,"about_ca_system_score_gemma":0.0002660241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001936763,"about_ca_topic_score_gemma":0.000009141268,"domain_scores_codex":[0.9945391,0.001420771,0.0003124903,0.001296371,0.001455844,0.0009753829],"domain_scores_gemma":[0.9974976,0.0000529639,0.00006688418,0.001597413,0.0006003676,0.0001848235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002105393,0.00001793116,0.000005832699,0.0003195808,0.002315887,0.0003035689,0.00003245033,0.000002903936,0.02348388,0.000001046275,0.8230963,0.1503995],"study_design_scores_gemma":[0.0006258994,0.00008820816,0.000008614838,0.00004445055,0.0001418845,0.00005495799,0.00004420089,0.000005661501,0.05209852,0.0000303871,0.946454,0.0004031766],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02195728,0.9730843,0.0003761377,0.002249082,0.0004306266,0.000803093,0.0002144325,0.00002666971,0.0008584271],"genre_scores_gemma":[0.003111391,0.8998802,0.0002641437,0.05660461,0.01488564,0.001359047,0.008428665,0.000502914,0.0149634],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1499963,"threshold_uncertainty_score":0.9998442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03484279349075336,"score_gpt":0.2914234663635707,"score_spread":0.2565806728728174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}