{"id":"W3133529542","doi":"10.1002/hep.31796","title":"DNA Methylation Signatures Reveal the Diversity of Processes Remodeling Hepatocellular Carcinoma Methylomes","year":2021,"lang":"en","type":"article","venue":"Hepatology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; National Cancer Institute; Assistance publique-Hôpitaux de Paris; Fondation Mérieux; Agència de Gestió d'Ajuts Universitaris i de Recerca; Associazione Italiana per la Ricerca sul Cancro; Fondation pour la Recherche Médicale; Styrelsen för Internationellt Utvecklingssamarbete; Institut National Du Cancer; Alliance Nationale pour les Sciences de la Vie et de la Santé; Bristol-Myers Squibb; Generalitat de Catalunya; Cancer Research UK; U.S. Department of Defense","keywords":"Hepatocellular carcinoma; DNA methylation; Methylation; Biology; Computational biology; Cancer research; DNA; Genetics; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003141859,0.0003168022,0.000270166,0.0006972124,0.0001359905,0.0003621926,0.0001688418,0.0001957587,0.0007478797],"category_scores_gemma":[0.000960924,0.0001417471,0.0003935666,0.0004571948,0.000185974,0.0002266484,0.0003148054,0.0002563122,0.0001366646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000291641,"about_ca_system_score_gemma":0.0003032381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002628354,"about_ca_topic_score_gemma":0.003319492,"domain_scores_codex":[0.9998738,0.00003225568,0.000006930887,0.00004223508,0.00002422206,0.00002060595],"domain_scores_gemma":[0.9997143,0.0001322805,0.00005495982,0.00003851269,0.00003753908,0.00002235233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001224505,0.0001032271,0.3660761,0.000289724,0.0005125811,0.0001909327,0.0003498702,0.09225568,0.4067304,0.002318856,0.0005993268,0.1293488],"study_design_scores_gemma":[0.00002634058,0.0001984259,0.4100366,0.00002118322,0.0002750123,0.0003841971,0.0001510678,0.5107575,0.06996367,0.00645676,0.001688875,0.00004028734],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517344,0.0004143014,0.04620395,0.00005253936,0.000003725742,0.00002600319,0.0006366989,0.0002618991,0.0006664779],"genre_scores_gemma":[0.9919339,0.00009496789,0.007218337,0.000008117958,0.000003443837,0.00001090735,0.0005333797,0.00001829214,0.0001786121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002628354,"threshold_uncertainty_score":0.005226076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0231214741395727,"score_gpt":0.2522084749953278,"score_spread":0.2290870008557551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}