{"id":"W3133529542","doi":"10.1002/hep.31796","title":"DNA Methylation Signatures Reveal the Diversity of Processes Remodeling Hepatocellular Carcinoma Methylomes","year":2021,"lang":"en","type":"article","venue":"Hepatology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; National Cancer Institute; Assistance publique-Hôpitaux de Paris; Fondation Mérieux; Agència de Gestió d'Ajuts Universitaris i de Recerca; Associazione Italiana per la Ricerca sul Cancro; Fondation pour la Recherche Médicale; Styrelsen för Internationellt Utvecklingssamarbete; Institut National Du Cancer; Alliance Nationale pour les Sciences de la Vie et de la Santé; Bristol-Myers Squibb; Generalitat de Catalunya; Cancer Research UK; U.S. Department of Defense","keywords":"Hepatocellular carcinoma; DNA methylation; Methylation; Biology; Computational biology; Cancer research; DNA; Genetics; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003142981,0.0001272444,0.0002011276,0.00003894777,0.0001901504,0.000009277867,0.0001839558,0.000218959,0.00001868374],"category_scores_gemma":[0.0004035422,0.000104965,0.00009249298,0.0001938066,0.00009701077,0.0000042888,0.0003193647,0.0001059076,0.000001752978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001135172,"about_ca_system_score_gemma":0.0001884381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007517765,"about_ca_topic_score_gemma":0.0001089098,"domain_scores_codex":[0.9988457,0.0002454726,0.0002488917,0.0003206694,0.0001547653,0.0001845039],"domain_scores_gemma":[0.9989446,0.00007822354,0.0001504851,0.0003518432,0.0004342773,0.00004058938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003372013,0.00003047607,0.2852205,0.00006717509,0.00004047562,0.000006969007,0.0001456394,0.0001207289,0.7130352,0.0001904864,0.0000900105,0.00101868],"study_design_scores_gemma":[0.000223883,0.00007729118,0.008922407,0.000005746604,0.00004316917,0.000007053082,0.00009216587,0.0009913772,0.9826195,0.001949365,0.00494016,0.0001279182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775744,0.01674694,0.004721772,0.000242482,0.0001436777,0.0001174147,0.0000151604,0.000008053948,0.0004301184],"genre_scores_gemma":[0.9975948,0.0007513898,0.001096193,0.0001200131,0.00009788378,0.000006477198,0.0001137406,0.0000132246,0.0002062331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.276298,"threshold_uncertainty_score":0.428035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0231214741395727,"score_gpt":0.2522084749953278,"score_spread":0.2290870008557551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}