{"id":"W3133567567","doi":"10.1016/j.molmet.2021.101207","title":"Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist","year":2021,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Novo Nordisk Foundation Center for Basic Metabolic Research; Carlsbergfondet; Novo Nordisk Fonden; Københavns Universitet","keywords":"Agonist; Hormone; Pharmacology; Chemistry; Endocrinology; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008089099,0.0002165189,0.0004381438,0.00009542155,0.0000476676,0.00002649015,0.0000881371,0.00003909582,0.00006448119],"category_scores_gemma":[0.0001413399,0.0002016563,0.0001497567,0.0003407156,0.00005338556,0.0001212819,0.00006993522,0.0001558693,0.00001551278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000428394,"about_ca_system_score_gemma":0.0001545564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007966252,"about_ca_topic_score_gemma":0.00000741341,"domain_scores_codex":[0.9986662,0.0001071329,0.000226183,0.0003786999,0.000324356,0.0002974832],"domain_scores_gemma":[0.9989334,0.00001569001,0.0001137013,0.0003893918,0.000353773,0.0001940065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002047189,0.0008843307,0.0003921825,0.0000372719,0.0003542091,0.0003782211,0.0001449369,0.000003439136,0.9826098,0.001522714,0.0005560751,0.0129121],"study_design_scores_gemma":[0.002396427,0.0005245174,0.04044154,0.00006221971,0.0008020753,0.00003773251,0.0002463919,0.00004943278,0.9519415,0.0003564333,0.002949422,0.0001922737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910876,0.001037963,0.0009408009,0.0004312628,0.00006364466,0.0003458955,0.00002746905,0.00005717228,0.006008182],"genre_scores_gemma":[0.9929841,0.00002936882,0.005383744,0.0005182731,0.00004342734,0.00003783293,0.0002557074,0.00003703709,0.0007104831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04004936,"threshold_uncertainty_score":0.8223307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011049829037717,"score_gpt":0.2513204844033388,"score_spread":0.2412099861129617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}