{"id":"W3133573753","doi":"10.1186/s12891-021-04648-0","title":"Randomised, double-blind comparison of a fixed co-formulation of intra-articular polynucleotides and hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis: two-year follow-up","year":2021,"lang":"en","type":"article","venue":"BMC Musculoskeletal Disorders","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Osteoarthritis; Viscosupplementation; Hyaluronic acid; Adverse effect; WOMAC; Clinical endpoint; Physical therapy; Body mass index; Internal medicine; Interim analysis; Randomized controlled trial; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005139119,0.00262261,0.009224537,0.00130852,0.0007901969,0.001698258,0.002195912,0.004523366,0.009106419],"category_scores_gemma":[0.005889644,0.001712663,0.002638701,0.001155176,0.003213987,0.001755381,0.000855833,0.003312901,0.001765799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001101787,"about_ca_system_score_gemma":0.002100966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001070061,"about_ca_topic_score_gemma":0.001646578,"domain_scores_codex":[0.9965705,0.001732683,0.0004017349,0.0005718018,0.0003080788,0.000415166],"domain_scores_gemma":[0.9958249,0.001474345,0.0008166171,0.0005276148,0.0004401426,0.0009162801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9886349,0.006485821,0.00009649073,0.0002660266,0.000233654,0.00001045693,0.00002396328,0.00008235669,0.001367586,0.00003532658,0.0001010195,0.002662318],"study_design_scores_gemma":[0.9178348,0.08087019,0.0004274073,0.00001462223,0.0001671073,0.000006861508,0.0000100536,0.0001750685,0.000304067,0.000045977,0.0001338344,0.00001008194],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746553,0.002878391,0.001652743,0.0003697882,0.002049784,0.01573645,0.001013065,0.0002427737,0.001401728],"genre_scores_gemma":[0.9566083,0.001992787,0.004501999,0.0007013832,0.001328361,0.02902843,0.0008370264,0.00005495529,0.004946624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009224537,"threshold_uncertainty_score":0.03046405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02698094004324209,"score_gpt":0.3081905496919481,"score_spread":0.281209609648706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}