{"id":"W3133576100","doi":"10.1001/jamaoncol.2021.0019","title":"Assessment of Immune Checkpoint Inhibitors and Genomic Alterations by Body Mass Index in Advanced Renal Cell Carcinoma","year":2021,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System; Juravinski Cancer Centre","funders":"Genentech; Ipsen; Pfizer; Bristol-Myers Squibb","keywords":"Medicine; Renal cell carcinoma; Body mass index; Clear cell renal cell carcinoma; Internal medicine; Oncology; Vascular endothelial growth factor; Immune checkpoint; Immune system; Carcinoma; Cancer research; Cancer; Immunotherapy; VEGF receptors; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000345013,0.0001408123,0.0002679908,0.0009063995,0.00020827,0.0003735071,0.0001996981,0.0002321381,0.001401556],"category_scores_gemma":[0.0008660486,0.0001358087,0.0002013291,0.0009599294,0.0001744793,0.0001960204,0.0001828268,0.0004001166,0.0001933355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003041586,"about_ca_system_score_gemma":0.0002312986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001244906,"about_ca_topic_score_gemma":0.002754241,"domain_scores_codex":[0.9997866,0.00003867868,0.00001811007,0.00004767856,0.00007721175,0.00003176558],"domain_scores_gemma":[0.9995942,0.0000744572,0.0001765028,0.00002113219,0.00006221222,0.00007161928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002049938,0.0002266284,0.962016,0.00007829685,0.0001530864,0.0001862407,0.00006828021,0.0004047286,0.01384339,0.0000727006,0.0003394277,0.02056137],"study_design_scores_gemma":[0.00003142057,0.0006142894,0.9931836,0.00001201123,0.00006519347,0.0004060803,0.0000772852,0.0008615002,0.003544176,0.000102612,0.001095353,0.000006368336],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954046,0.002128286,0.0003902093,0.00008895033,0.00001295629,0.00004980951,0.0008105591,0.00001211538,0.00110255],"genre_scores_gemma":[0.9973069,0.0005978689,0.0007920666,0.00009819947,0.00001909222,0.00004895318,0.0006213404,0.000004592465,0.0005108682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001401556,"threshold_uncertainty_score":0.004688621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01056701007371909,"score_gpt":0.2857712194387649,"score_spread":0.2752042093650459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}