{"id":"W3133579575","doi":"10.1016/j.neurobiolaging.2021.02.018","title":"LRRK2 p.M1646T is associated with glucocerebrosidase activity and with Parkinson's disease","year":2021,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University; Montreal Neurological Institute and Hospital","funders":"Brookdale Foundation Group; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Canada First Research Excellence Fund; National Center for Advancing Translational Sciences; Michael J. Fox Foundation for Parkinson's Research","keywords":"LRRK2; Odds ratio; Cohort; Confidence interval; Parkinson's disease; Glucocerebrosidase; Internal medicine; Medicine; Gastroenterology; Dried blood spot; Cohort study; Disease; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003556735,0.001951386,0.0008679206,0.001291138,0.001071823,0.0007322162,0.0008078341,0.002781873,0.005861831],"category_scores_gemma":[0.001986441,0.0003521857,0.001315556,0.00142332,0.0009524213,0.0005182207,0.0005411782,0.001200241,0.001470718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003136568,"about_ca_system_score_gemma":0.0002671171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00174465,"about_ca_topic_score_gemma":0.001223442,"domain_scores_codex":[0.999331,0.0001293622,0.0001349456,0.0002074516,0.000112651,0.00008458456],"domain_scores_gemma":[0.9986319,0.0002891213,0.0007513654,0.00005186088,0.0001015096,0.000174116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.008911412,0.0009642615,0.3564741,0.0006333459,0.00218491,0.4396697,0.0009642868,0.001328054,0.157285,0.001708964,0.005675279,0.02420064],"study_design_scores_gemma":[0.0007890846,0.001356755,0.5263978,0.0003217297,0.002454602,0.4278671,0.0008509429,0.005140247,0.01713122,0.003649315,0.01379405,0.0002471727],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909512,0.002140098,0.001368603,0.001207314,0.0003430939,0.00005760059,0.0009777034,0.00009547256,0.002858965],"genre_scores_gemma":[0.9968377,0.0002984118,0.0004868738,0.0002945782,0.0002053497,0.00002059036,0.0004268486,0.00003670645,0.001392918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005861831,"threshold_uncertainty_score":0.01960975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121467939546406,"score_gpt":0.2384893114516862,"score_spread":0.2263425174970456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}