{"id":"W3133587423","doi":"10.1186/s13148-021-01037-1","title":"Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells","year":2021,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université Laval; Université de Montréal; McGill University","funders":"CIHR Skin Research Training Centre; Fonds de Recherche du Québec-Société et Culture","keywords":"Lung cancer; Combination therapy; Cancer research; Cancer; PARP inhibitor; Medicine; Methyltransferase; Targeted therapy; Pharmacology; Internal medicine; Biology; Poly ADP ribose polymerase; Biochemistry; Enzyme; DNA; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646279,0.0001712395,0.000292602,0.00002326929,0.00004021083,0.0000131479,0.0001047356,0.0003828016,0.000009138583],"category_scores_gemma":[0.000260756,0.0001791556,0.0001250192,0.0001448862,0.0001484617,0.000001504711,0.0001613343,0.0001495994,0.000002875562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001736486,"about_ca_system_score_gemma":0.0003385892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001132434,"about_ca_topic_score_gemma":0.00004696151,"domain_scores_codex":[0.9985584,0.0001186539,0.0005338561,0.0004524026,0.0001155114,0.0002211987],"domain_scores_gemma":[0.998867,0.000144057,0.0002057017,0.0004006037,0.000232766,0.0001498439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004396412,0.0001478235,0.01923436,0.0004131987,0.00009706463,0.000009024621,0.00002712964,0.004450906,0.9650814,0.000003901913,0.001762249,0.008728987],"study_design_scores_gemma":[0.0008145605,0.0002882456,0.01089352,0.0001355352,0.0001557381,5.466886e-7,0.000009246074,0.002173971,0.9808034,0.00001632368,0.004486994,0.0002218826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793357,0.01729309,0.001322622,0.00004408931,0.001500831,0.000234711,0.00001399707,0.000007151242,0.0002478023],"genre_scores_gemma":[0.9794525,0.01812347,0.0009418836,0.0001541449,0.0006054311,0.00001169234,0.00005621456,0.00003649705,0.0006181611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01572205,"threshold_uncertainty_score":0.7305753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003112780038929,"score_gpt":0.2924846336181623,"score_spread":0.2824535058177731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}