{"id":"W3133587423","doi":"10.1186/s13148-021-01037-1","title":"Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells","year":2021,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université Laval; Université de Montréal; McGill University","funders":"CIHR Skin Research Training Centre; Fonds de Recherche du Québec-Société et Culture","keywords":"Lung cancer; Combination therapy; Cancer research; Cancer; PARP inhibitor; Medicine; Methyltransferase; Targeted therapy; Pharmacology; Internal medicine; Biology; Poly ADP ribose polymerase; Biochemistry; Enzyme; DNA; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458627,0.0005560565,0.0005553286,0.000460442,0.0001805379,0.0002346398,0.0003004407,0.0002551046,0.002026728],"category_scores_gemma":[0.00009035265,0.0001465321,0.0005439532,0.0004280576,0.0001146057,0.000176207,0.0002528609,0.0004353692,0.0003943288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002142637,"about_ca_system_score_gemma":0.0002761555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004332894,"about_ca_topic_score_gemma":0.001522804,"domain_scores_codex":[0.9998697,0.00002041591,0.00001405214,0.00002635068,0.00004343026,0.00002601434],"domain_scores_gemma":[0.9999399,0.00001285604,0.00001433061,0.000006557586,0.000009374882,0.00001689343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009588493,0.0005158557,0.001070381,0.0004958644,0.0001035476,0.000185652,0.00003180502,0.0007695266,0.9725258,0.0001185411,0.0005283072,0.02269582],"study_design_scores_gemma":[0.0001908601,0.006162371,0.006634052,0.00002440845,0.0002036399,0.0007311497,0.00003536474,0.001385163,0.977958,0.0000479179,0.006612435,0.00001462049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758833,0.01497308,0.001781009,0.0001930324,0.000100808,0.0001944837,0.001016731,0.0001508617,0.005706623],"genre_scores_gemma":[0.9891559,0.005469661,0.002229081,0.0001083241,0.00002596697,0.00009462122,0.0008848687,0.00001291626,0.00201871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002026728,"threshold_uncertainty_score":0.006780088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003112780038929,"score_gpt":0.2924846336181623,"score_spread":0.2824535058177731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}