{"id":"W3133587783","doi":"10.1038/s41467-021-21873-2","title":"Protein context shapes the specificity of SH3 domain-mediated interactions in vivo","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Institut National de la Recherche Scientifique; Centre hospitalier de l'Université Laval; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Université Laval; PROTEO","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Centre Hospitalier Universitaire de Québec; Canadian Institutes of Health Research; Mitacs; Fonds de Recherche du Québec - Santé; National Trust for Historic Preservation; Université Laval","keywords":"SH3 domain; Computational biology; Biology; Context (archaeology); Protein domain; Protein–protein interaction; Plasma protein binding; Genetics; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Gene; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002783521,0.0002274733,0.0002437317,0.000178936,0.0001967876,0.0005378685,0.0002291138,0.0003270148,0.001350836],"category_scores_gemma":[0.0003782418,0.0002783891,0.0001542295,0.0001475596,0.0004384924,0.0003496037,0.0004242083,0.0005271753,0.0006407785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003288315,"about_ca_system_score_gemma":0.000210653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004702044,"about_ca_topic_score_gemma":0.0009974935,"domain_scores_codex":[0.9998005,0.00003576506,0.00001337956,0.00005969374,0.00004377328,0.00004701466],"domain_scores_gemma":[0.9996787,0.0001082522,0.00006724831,0.00002658319,0.00002656142,0.00009269237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006821314,0.000009043251,0.0007727704,0.00001404113,0.000005285361,0.00002444982,0.000007942541,0.0001823147,0.9982405,0.00008604909,0.00002240952,0.0005670862],"study_design_scores_gemma":[0.00001963754,0.0001169543,0.02521013,0.000007199199,0.00002222506,0.0002811662,0.00006516063,0.00717139,0.9654441,0.0003141375,0.001333132,0.00001472097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971583,0.0003752607,0.00163926,0.0000415023,0.000008354621,0.000003343068,0.00005162543,0.00002798636,0.0006943493],"genre_scores_gemma":[0.9988598,0.0002103048,0.0005256454,0.00004538164,0.000002757214,0.000003509403,0.00007650609,0.00002005419,0.0002561537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350836,"threshold_uncertainty_score":0.004519045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02528543772020201,"score_gpt":0.3228426760579649,"score_spread":0.2975572383377629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}