{"id":"W3133609674","doi":"10.1093/jcag/gwab002.041","title":"A43 LONG-TERM EFFICACY AND SAFETY OF OBETICHOCLIC ACID IN PRIMARY BILIARY CHOLANGITIS: RESPONDER ANALYSIS OF OVER 5 YEARS OF TREATMENT IN THE POISE TRIAL","year":2021,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Obeticholic acid; Medicine; Clinical endpoint; Internal medicine; Ursodeoxycholic acid; Gastroenterology; Placebo; Bile acid; Adverse effect; Bilirubin; Randomized controlled trial; Agonist; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005305429,0.0008374102,0.003045297,0.0003433612,0.000440069,0.001232215,0.0004508293,0.001614896,0.002415527],"category_scores_gemma":[0.003440796,0.0003648167,0.003244608,0.0004198358,0.0008910206,0.00123893,0.0005980443,0.002393552,0.0003828182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004564007,"about_ca_system_score_gemma":0.000553655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000369447,"about_ca_topic_score_gemma":0.0005944842,"domain_scores_codex":[0.997682,0.001517059,0.0001144922,0.0002409248,0.0002131256,0.0002323536],"domain_scores_gemma":[0.9968879,0.0009086427,0.001075071,0.0003405049,0.0002082058,0.0005796227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9597195,0.003504448,0.01214668,0.0004127818,0.003165913,0.0001251283,0.0001089655,0.0006644498,0.004642046,0.0001031937,0.0005983877,0.01480849],"study_design_scores_gemma":[0.5378472,0.3311288,0.1167625,0.0001182965,0.005595681,0.0003887544,0.0001624887,0.001773941,0.002339996,0.000515704,0.003278964,0.00008758557],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948914,0.003031027,0.0002607332,0.0002053387,0.00007340865,0.0003486149,0.0004179455,0.0000207341,0.0007509092],"genre_scores_gemma":[0.9968914,0.000758072,0.0001798003,0.0002285753,0.0001647722,0.0004157689,0.0006829018,0.000005768042,0.0006728551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005305429,"threshold_uncertainty_score":0.02805811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101579841242829,"score_gpt":0.2577601125777458,"score_spread":0.2467443141653175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}