{"id":"W3133611730","doi":"10.1186/s12974-021-02125-y","title":"Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity","year":2021,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Arthritis Network; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"CCR2; Medicine; Dorsal root ganglion; Nociceptor; Calcitonin gene-related peptide; Sensitization; Nociception; Inflammation; Neuroinflammation; Sciatic nerve; Neuroscience; Chemokine; Internal medicine; Immunology; Chemokine receptor; Receptor; Anatomy; Neuropeptide; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006716994,0.0001157609,0.0002472279,0.00009871941,0.0000760768,0.00002426269,0.00006092732,0.00005357494,0.000008912136],"category_scores_gemma":[0.0008918028,0.00006895633,0.00008379792,0.0002789231,0.00002129594,0.000131972,0.00004608747,0.0001964246,0.000001171348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000950247,"about_ca_system_score_gemma":0.0001112086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003111249,"about_ca_topic_score_gemma":0.0002730508,"domain_scores_codex":[0.9986082,0.000356564,0.0004374364,0.0001181175,0.0003708479,0.0001087789],"domain_scores_gemma":[0.9990423,0.0001492091,0.0003021768,0.0001908861,0.0002557158,0.00005976145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000167893,0.00006995919,0.002325794,0.00004068593,0.00003631131,0.0001984896,0.00292773,0.0001803121,0.9675972,0.0009007379,0.00000892734,0.02554597],"study_design_scores_gemma":[0.001975335,0.0005328262,0.19355,0.0003420017,0.0001495649,0.0004223309,0.001130103,0.01113413,0.7801238,0.00979385,0.000729747,0.0001163523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953737,0.0001677098,0.0005517334,0.003364005,0.0001477781,0.0002455542,6.457149e-7,0.000004854798,0.0001440722],"genre_scores_gemma":[0.9992038,0.00002782417,0.0004980101,0.00008946473,0.0001214197,0.000003276689,0.000002504392,0.00001153863,0.0000421704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1912242,"threshold_uncertainty_score":0.2811958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00624602446627526,"score_gpt":0.2221787112932594,"score_spread":0.2159326868269842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}