{"id":"W3133617167","doi":"10.1111/acel.13331","title":"A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition","year":2021,"lang":"en","type":"article","venue":"Aging Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Telomere; Telomerase; Biology; Regulator; Telomerase reverse transcriptase; Downregulation and upregulation; Gene; Mdm2; DNA damage; Senescence; Cancer research; Cell biology; Molecular biology; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000226219,0.0007620331,0.000430314,0.0003086516,0.0002335171,0.0004770451,0.0005395688,0.0004725811,0.001967635],"category_scores_gemma":[0.0002577853,0.0001525885,0.0002443546,0.0001515538,0.0003983181,0.0003106288,0.0003414228,0.0005735456,0.0006884424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004746411,"about_ca_system_score_gemma":0.0002916819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003569992,"about_ca_topic_score_gemma":0.0006691346,"domain_scores_codex":[0.9998437,0.0000130895,0.00001194751,0.00006379536,0.00003979842,0.00002762035],"domain_scores_gemma":[0.9998575,0.00001673359,0.00006792104,0.0000170764,0.00001391021,0.00002675758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009908969,0.0000157931,0.0003949178,0.0000393024,0.00000551498,0.0001971918,0.000007272827,0.0001724837,0.9950942,0.0001375164,0.0001375312,0.003699251],"study_design_scores_gemma":[0.00002422582,0.0001726281,0.003803298,0.000009298346,0.00001859651,0.0009204526,0.0000189308,0.001336187,0.9881578,0.0001159721,0.00541333,0.000009155394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802045,0.005956435,0.008750997,0.0003951646,0.0001162229,0.00005036857,0.0007461259,0.0009625127,0.002817557],"genre_scores_gemma":[0.9923736,0.0009873414,0.003008212,0.00007015492,0.00001988642,0.00003062805,0.0004158602,0.00006061515,0.003033722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001967635,"threshold_uncertainty_score":0.006582379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440015513496418,"score_gpt":0.2405389679816913,"score_spread":0.2261388128467272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}