{"id":"W3133617167","doi":"10.1111/acel.13331","title":"A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition","year":2021,"lang":"en","type":"article","venue":"Aging Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Telomere; Telomerase; Biology; Regulator; Telomerase reverse transcriptase; Downregulation and upregulation; Gene; Mdm2; DNA damage; Senescence; Cancer research; Cell biology; Molecular biology; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002037022,0.0002949198,0.0004119407,0.0001781779,0.0001768839,0.00005838239,0.00009135131,0.000148234,0.0002239828],"category_scores_gemma":[0.0001139158,0.0002958786,0.0001843975,0.0005876351,0.0001099912,0.0001642032,0.00008807989,0.0003667345,0.0002131547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001513553,"about_ca_system_score_gemma":0.0002909594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009165618,"about_ca_topic_score_gemma":0.00002469303,"domain_scores_codex":[0.9979271,0.00004821879,0.0004018018,0.0006226336,0.000461736,0.0005384948],"domain_scores_gemma":[0.998591,0.00008734904,0.0001172335,0.0006520739,0.0002170617,0.0003352673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005936294,0.0005670852,0.008956701,0.0003604173,0.00005220653,0.001116694,0.0009870782,0.0000253542,0.9693615,0.0001727659,0.007488968,0.01085181],"study_design_scores_gemma":[0.004574614,0.000123665,0.02641068,0.0006993861,0.0001809908,0.0004077388,0.00137035,0.0006063859,0.9101459,0.00009858773,0.05465401,0.0007276926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807685,0.001310441,0.000829588,0.002329976,0.0004796152,0.0002528002,0.00001951271,0.0002705691,0.01373898],"genre_scores_gemma":[0.9832115,0.0002756762,0.003476065,0.004625252,0.0003988712,0.0000131852,0.0002127005,0.00006504691,0.007721659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05921566,"threshold_uncertainty_score":0.9999493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440015513496418,"score_gpt":0.2405389679816913,"score_spread":0.2261388128467272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}