{"id":"W3133621783","doi":"10.1007/s10989-021-10178-z","title":"A Skate Skin Hydrolysate Restores Cognitive Function in 5XFAD Alzheimer Disease Mice Model by Suppressing Amyloid-β Accumulation via Upregulation of ERK-CREB","year":2021,"lang":"en","type":"article","venue":"International Journal of Peptide Research and Therapeutics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Ministry of Oceans and Fisheries","keywords":"CREB; Morris water navigation task; MAPK/ERK pathway; Alzheimer's disease; Downregulation and upregulation; Amyloid beta; Medicine; Endocrinology; Internal medicine; Pharmacology; Neuroscience; Disease; Biology; Cell biology; Kinase; Hippocampus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001027242,0.0005144184,0.0003204159,0.0002931958,0.0001522223,0.0001895633,0.0001661317,0.0002785085,0.002194199],"category_scores_gemma":[0.00006826691,0.00013032,0.0004850247,0.0001106095,0.0002142868,0.0002930128,0.0001370177,0.0007086128,0.0003371379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000128069,"about_ca_system_score_gemma":0.0001755788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006488319,"about_ca_topic_score_gemma":0.0007533615,"domain_scores_codex":[0.9999441,0.000005194489,0.000005689648,0.00001365644,0.00001076553,0.00002061141],"domain_scores_gemma":[0.9999584,0.000003030786,0.00001521562,0.000003705861,0.000006145679,0.00001346351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001431705,0.0001688585,0.0001699458,0.0001198304,0.00002536268,0.00008858079,0.00001585982,0.0000415872,0.9958259,0.00006892083,0.00009373322,0.001949781],"study_design_scores_gemma":[0.0001684305,0.001992409,0.00718806,0.00002088259,0.0001459261,0.000420901,0.00009184906,0.000470229,0.9865862,0.0001224726,0.002778585,0.00001401234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954319,0.001785053,0.001338778,0.0001327312,0.00007588779,0.00002948462,0.0003777977,0.00008104349,0.0007472694],"genre_scores_gemma":[0.993661,0.001618451,0.000881817,0.00006470057,0.00001728394,0.0000393656,0.000494908,0.00001622664,0.003206152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002194199,"threshold_uncertainty_score":0.007340312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1037153253847792,"score_gpt":0.4182834284514798,"score_spread":0.3145681030667005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}