{"id":"W3133660370","doi":"10.3389/fcell.2021.634512","title":"The Interplay Between Non-coding RNAs and Insulin-Like Growth Factor Signaling in the Pathogenesis of Neoplasia","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centennial College","funders":"","keywords":"Pathogenesis; PI3K/AKT/mTOR pathway; Biology; Insulin resistance; Signal transduction; Insulin-like growth factor; MAPK/ERK pathway; Bioinformatics; Growth factor; Insulin; Cancer research; Neuroscience; Genetics; Immunology; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005250481,0.0003072424,0.0007451026,0.0001664167,0.0001042206,0.00003364339,0.0003795144,0.0005149362,0.000003305004],"category_scores_gemma":[0.00008256013,0.0002001249,0.0001193741,0.000264239,0.0001980118,0.000003196323,0.000430547,0.0003860243,7.629419e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006863286,"about_ca_system_score_gemma":0.0003435136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003116539,"about_ca_topic_score_gemma":0.00003710813,"domain_scores_codex":[0.9980319,0.0004371538,0.0005379962,0.0005226823,0.0001079343,0.0003623103],"domain_scores_gemma":[0.9994041,0.0001558298,0.0001683978,0.0001801824,0.0000354961,0.00005596142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004896519,0.00004140424,0.0014248,0.001579726,0.0002829861,0.00003706695,0.0004783178,3.83128e-7,0.02117861,0.00001721408,0.0006000153,0.9743105],"study_design_scores_gemma":[0.001391895,0.0004276227,0.0005255093,0.002506599,0.0001789801,0.0001401602,0.002375941,0.00001030391,0.04085104,0.0001458896,0.9504336,0.001012469],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004181601,0.9907717,0.003984023,0.00001465272,0.000323995,0.0005005166,0.00007187863,0.00000209525,0.0001495949],"genre_scores_gemma":[0.01964581,0.9780976,0.001702086,0.00004021524,0.00005541394,0.00007632577,0.0003084388,0.00002694321,0.00004717744],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.973298,"threshold_uncertainty_score":0.8160855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01603069308588242,"score_gpt":0.2891197120552898,"score_spread":0.2730890189694074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}