{"id":"W3133661037","doi":"10.1111/bph.15432","title":"Clinical applications for exosomes: Are we there yet?","year":2021,"lang":"en","type":"review","venue":"British Journal of Pharmacology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Great Ormond Street Hospital Biomedical Research Centre; Medical Research Council Canada; Medical Research Council; National Institute for Health and Care Research","keywords":"Microvesicles; Exosome; Clinical trial; Immunogenicity; Computational biology; Extracellular vesicles; Good manufacturing practice; Medicine; Bioinformatics; Biology; Biotechnology; Immunology; Cell biology; microRNA; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006874865,0.0002592685,0.001337131,0.00006290161,0.00008907726,0.00004521052,0.0006961516,0.0005713794,0.0001641148],"category_scores_gemma":[0.0001908461,0.0002871578,0.001552656,0.0001103977,0.0001701361,0.000004816162,0.0001682499,0.0005870896,0.00000953178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000351223,"about_ca_system_score_gemma":0.0008608432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.32178e-7,"about_ca_topic_score_gemma":0.000003091084,"domain_scores_codex":[0.9972903,0.0005808232,0.001289018,0.0004182564,0.0001303478,0.0002913272],"domain_scores_gemma":[0.9975115,0.0002124096,0.001445384,0.0001945868,0.000416461,0.00021968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001940835,0.0003648385,0.000004353378,0.002672982,0.0008472197,0.0004695903,0.000001141791,0.00000145391,0.0003472979,0.00001059923,0.1553398,0.8399214],"study_design_scores_gemma":[0.0008841806,0.0001512051,0.000001973161,0.002564325,0.001787696,0.003598948,0.00001926453,7.338397e-7,0.0001813853,0.00005176743,0.9905003,0.0002581923],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005531047,0.9949346,0.002523765,0.0001058831,0.001155787,0.0007966692,0.0003566552,0.000005638962,0.00006574729],"genre_scores_gemma":[0.00004839229,0.9930202,0.001590705,0.0002694222,0.00384265,0.0002297119,0.0002285455,0.00008194071,0.0006884793],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8396631,"threshold_uncertainty_score":0.999958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07114496749844938,"score_gpt":0.4424549515106085,"score_spread":0.3713099840121591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}