{"id":"W3133661037","doi":"10.1111/bph.15432","title":"Clinical applications for exosomes: Are we there yet?","year":2021,"lang":"en","type":"review","venue":"British Journal of Pharmacology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Great Ormond Street Hospital Biomedical Research Centre; Medical Research Council Canada; Medical Research Council; National Institute for Health and Care Research","keywords":"Microvesicles; Exosome; Clinical trial; Immunogenicity; Computational biology; Extracellular vesicles; Good manufacturing practice; Medicine; Bioinformatics; Biology; Biotechnology; Immunology; Cell biology; microRNA; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002351202,0.0007419781,0.001738658,0.0008979774,0.0004076668,0.00272645,0.0008801612,0.00274709,0.005601908],"category_scores_gemma":[0.00251148,0.0003402962,0.0008104939,0.000751625,0.0009776806,0.004217758,0.001143409,0.00345093,0.003582994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006105167,"about_ca_system_score_gemma":0.001548408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000531102,"about_ca_topic_score_gemma":0.000968082,"domain_scores_codex":[0.9994829,0.0001402034,0.00007533742,0.00006241006,0.0001905891,0.0000485885],"domain_scores_gemma":[0.9984872,0.0009328506,0.0001189107,0.00004451903,0.0003116619,0.0001048659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001065511,0.00007276014,0.0002003456,0.01024549,0.00005968225,0.0003328066,0.0001093213,0.0001938369,0.00201025,0.01038207,0.03191641,0.9443705],"study_design_scores_gemma":[0.00003072942,0.0001301908,0.000310081,0.005112213,0.00006297846,0.001295042,0.0001187078,0.0000787963,0.0006176456,0.004536748,0.9876818,0.00002493737],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001177075,0.9950262,0.0003050438,0.003203048,0.0005311238,0.000009050363,0.00001462898,0.00001168628,0.0007815886],"genre_scores_gemma":[0.0009286831,0.9958647,0.0005794864,0.001263862,0.0005604541,0.00001766502,0.00002574713,0.000004031147,0.0007553136],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005601908,"threshold_uncertainty_score":0.01874024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07114496749844938,"score_gpt":0.4424549515106085,"score_spread":0.3713099840121591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}