{"id":"W3133663503","doi":"10.1016/j.jprot.2021.104182","title":"Protein feature analysis of heat shock induced ubiquitination sites reveals preferential modification site localization","year":2021,"lang":"en","type":"article","venue":"Journal of Proteomics","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"BC Cancer Agency; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Ubiquitin; Proteasome; Protein folding; Cell biology; Heat shock protein; Proteostasis; Proteolysis; Heat shock; Chemistry; Cytosol; Nuclear protein; Biochemistry; Protein degradation; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005249031,0.0001107926,0.0003390608,0.0003695915,0.00007508988,0.00007438973,0.0001155384,0.0001581396,0.0001502415],"category_scores_gemma":[0.0002844059,0.00009462122,0.0001547336,0.0009458511,0.00002208824,0.0003893205,0.00002919362,0.0001693157,0.000002921854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009500069,"about_ca_system_score_gemma":0.0001195618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009039188,"about_ca_topic_score_gemma":0.0000298604,"domain_scores_codex":[0.9985544,0.0001840038,0.0005672841,0.000167956,0.000406867,0.0001194558],"domain_scores_gemma":[0.9979212,0.00002343799,0.0006889367,0.0001959363,0.001117634,0.00005284647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000115892,0.00005079707,0.001083237,0.0000540968,0.00009471284,0.000001955234,0.000313629,0.00750751,0.9900475,0.0004418221,0.0001379406,0.0001509323],"study_design_scores_gemma":[0.000320106,0.0001326601,0.00601824,0.00006219416,0.0004468144,0.00001311191,0.0000738993,0.005985366,0.986071,0.0007361047,0.00004816536,0.00009234295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8874705,0.00007088852,0.111718,0.0002526908,0.0001660928,0.0002221448,0.00002223203,0.000009492543,0.0000679202],"genre_scores_gemma":[0.987451,0.00001365007,0.01202441,0.00005148972,0.0002216046,0.000006879875,0.00008510678,0.00001006691,0.0001357601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09998051,"threshold_uncertainty_score":0.3858541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0237870233472716,"score_gpt":0.2701497247151124,"score_spread":0.2463627013678408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}