{"id":"W3133669010","doi":"10.1101/2021.03.09.430613","title":"Niche signals regulate continuous transcriptional states in hematopoietic stem cells","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Boehringer Ingelheim Fonds; National Institutes of Health; Harvard University; Howard Hughes Medical Institute","keywords":"Biology; Niche; Haematopoiesis; Chromatin; Stem cell; Cell biology; Progenitor cell; Hematopoietic stem cell; Transcription factor; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005247956,0.0006652596,0.0007547581,0.0001598753,0.00009348586,0.0002412427,0.0005752206,0.0009182196,0.00005388104],"category_scores_gemma":[0.00002281999,0.0007581239,0.0003405323,0.0002637992,0.0001540504,0.00001273038,0.0002288575,0.0006764269,0.00001437583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000103533,"about_ca_system_score_gemma":0.0006075232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007289904,"about_ca_topic_score_gemma":0.00002614025,"domain_scores_codex":[0.9965774,0.0002516959,0.0008057792,0.001328247,0.0003646055,0.0006722711],"domain_scores_gemma":[0.9979803,0.00002992133,0.0002828257,0.001071362,0.0003900708,0.0002455312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008560465,0.0002934343,0.003141419,0.0004005301,0.0001642974,0.00008903265,0.00003365565,0.001003533,0.9945557,0.00004116983,0.0001885464,0.000003093434],"study_design_scores_gemma":[0.000919553,0.0000981866,0.005253879,0.0003961209,0.0000817387,8.501672e-8,0.00002146458,0.0002921109,0.9889135,0.000002659419,0.003148848,0.0008717989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893311,0.00582548,0.002641479,0.0001303732,0.001136246,0.0005726592,0.0002718201,0.0000840423,0.000006791751],"genre_scores_gemma":[0.9965903,0.00123572,0.001165969,0.0003390885,0.0003336048,0.00012572,0.000006271906,0.0001581259,0.00004515573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007259235,"threshold_uncertainty_score":0.999487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245702361676186,"score_gpt":0.2034814355197644,"score_spread":0.1910244119030025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}