{"id":"W3133669010","doi":"10.1101/2021.03.09.430613","title":"Niche signals regulate continuous transcriptional states in hematopoietic stem cells","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Boehringer Ingelheim Fonds; National Institutes of Health; Harvard University; Howard Hughes Medical Institute","keywords":"Biology; Niche; Haematopoiesis; Chromatin; Stem cell; Cell biology; Progenitor cell; Hematopoietic stem cell; Transcription factor; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059096,0.0001472453,0.0001919949,0.0002142625,0.0001356503,0.0003289742,0.00009261249,0.0001155606,0.001147809],"category_scores_gemma":[0.00008918453,0.0001358517,0.0001370631,0.000224352,0.0002412882,0.0001697184,0.000220261,0.0002024363,0.000403611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001821549,"about_ca_system_score_gemma":0.0001489424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003805751,"about_ca_topic_score_gemma":0.0006846354,"domain_scores_codex":[0.9999156,0.00000635324,0.000004108909,0.00003197156,0.00002672379,0.00001525939],"domain_scores_gemma":[0.999936,0.00001159759,0.00001593588,0.000008730685,0.0000129245,0.00001487002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004712594,0.000002337428,0.001046043,0.00001811367,0.000002047202,0.00001325848,0.00001796983,0.00007256844,0.9976146,0.00007058942,0.00003532925,0.001060061],"study_design_scores_gemma":[0.0000133745,0.00009432029,0.1238093,0.00001558124,0.00001534102,0.0001741011,0.0001301849,0.004101759,0.8675963,0.0005881003,0.003448781,0.0000129106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925889,0.000709586,0.003680425,0.00003508033,0.000008806029,0.000007619057,0.001939975,0.0001177921,0.0009119931],"genre_scores_gemma":[0.9928614,0.0003302966,0.002414475,0.00004065852,0.000008364298,0.0000150211,0.002889751,0.00005356391,0.001386307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001147809,"threshold_uncertainty_score":0.003839791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245702361676186,"score_gpt":0.2034814355197644,"score_spread":0.1910244119030025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}