{"id":"W3133720646","doi":"10.1172/jci140752","title":"Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Hôpital Maisonneuve-Rosemont; McGill University; Jewish General Hospital","funders":"Terry Fox Research Institute; Canadian Institutes of Health Research; H2020 European Research Council; Réseau de cancérologie Rossy; Narodowe Centrum Badań i Rozwoju; McGill University","keywords":"Melanoma; Cancer research; Immunotherapy; CD8; EIF4E; Immune system; Immune checkpoint; Phenotype; Tumor microenvironment; Immunology; Biology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001722403,0.0005089304,0.000328177,0.0002929583,0.0001028436,0.0002444781,0.0001853809,0.0002795042,0.00114585],"category_scores_gemma":[0.00009538762,0.0001684551,0.0002001989,0.000111689,0.0002050478,0.000178161,0.0001953066,0.0008729809,0.0002362509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002341416,"about_ca_system_score_gemma":0.0002055775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002913017,"about_ca_topic_score_gemma":0.0006103555,"domain_scores_codex":[0.9998075,0.00003295072,0.00002401898,0.00002994257,0.00004262717,0.00006284082],"domain_scores_gemma":[0.9998924,0.00001918159,0.00002964489,0.00001275945,0.000005552745,0.00004037095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003702115,0.0001338223,0.0001391161,0.0000305532,0.000006275985,0.00001845264,0.000008523374,0.0001530671,0.9975376,0.00007626192,0.00004647659,0.001479711],"study_design_scores_gemma":[0.00006068088,0.001537323,0.003009686,0.000007545431,0.00002185864,0.00008962554,0.00001646788,0.001432663,0.9919406,0.00004635331,0.001832349,0.000004962592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960963,0.0008447214,0.001124933,0.00009322789,0.00004572035,0.00004043072,0.0002908268,0.0001276673,0.001336088],"genre_scores_gemma":[0.9965646,0.0004758593,0.0009284303,0.00004099404,0.00001031364,0.00005133025,0.0002205146,0.0000140504,0.001693953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00114585,"threshold_uncertainty_score":0.003833234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08551406362731641,"score_gpt":0.397335359109645,"score_spread":0.3118212954823286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}