{"id":"W3133740787","doi":"10.1007/s40262-020-00983-y","title":"The Effect of Renal Impairment on the Pharmacokinetics and Safety of Talazoparib in Patients with Advanced Solid Tumors","year":2021,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; McGill University; Jewish General Hospital","funders":"National Center for Advancing Translational Sciences; Pfizer","keywords":"Medicine; Tolerability; Renal function; Pharmacokinetics; Cmax; Urology; Dosing; Adverse effect; Internal medicine; Kidney disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008635152,0.0002389155,0.0006507523,0.0001414942,0.0001888441,0.0003644575,0.0001080094,0.0001766463,0.0008326811],"category_scores_gemma":[0.001255977,0.00009080829,0.0003976761,0.000210451,0.0002787038,0.0002709107,0.0002170033,0.0004793447,0.0001069632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105039,"about_ca_system_score_gemma":0.0003348677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004993553,"about_ca_topic_score_gemma":0.00100267,"domain_scores_codex":[0.9995994,0.0001866553,0.00003525671,0.00003510463,0.0000836743,0.00005996826],"domain_scores_gemma":[0.9991697,0.0003125672,0.000302593,0.00003178273,0.00004736435,0.0001359878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07898168,0.003098148,0.6173544,0.0008427709,0.001173633,0.001856515,0.0003237294,0.005905996,0.1095668,0.0003388496,0.001210014,0.1793474],"study_design_scores_gemma":[0.002056671,0.05245765,0.9238169,0.00004272917,0.000529532,0.002327657,0.0001118998,0.003085367,0.01169383,0.0001945624,0.003655,0.00002829011],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970402,0.002040036,0.0001962391,0.0000811194,0.000007050099,0.00002319584,0.00005236484,0.000005794471,0.0005539877],"genre_scores_gemma":[0.9991263,0.000493493,0.0001069706,0.0000779753,0.00001685578,0.000008113689,0.00004579745,9.784555e-7,0.0001234987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008635152,"threshold_uncertainty_score":0.004566789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01753290672712802,"score_gpt":0.3691539646569015,"score_spread":0.3516210579297734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}