{"id":"W3133751538","doi":"10.1002/ctm2.337","title":"Aptamer‐SH2 superbinder‐based targeted therapy for pancreatic ductal adenocarcinoma","year":2021,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Cancer research; Pancreatic cancer; Stroma; Conjugate; Metastasis; Cancer; Immunofluorescence; Biology; Medicine; Chemistry; Pathology; Internal medicine; Antibody; Immunology; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000950979,0.0002545102,0.0002066578,0.0001769418,0.00008499175,0.0001396125,0.0001600842,0.0002435645,0.001245708],"category_scores_gemma":[0.00004902014,0.00009055906,0.0001786741,0.0001312231,0.0001230024,0.0001556896,0.0001722039,0.0003738578,0.0003027525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002182375,"about_ca_system_score_gemma":0.0000966378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001718776,"about_ca_topic_score_gemma":0.0002653583,"domain_scores_codex":[0.999934,0.000009080502,0.000004288479,0.00001545388,0.00002383415,0.00001340483],"domain_scores_gemma":[0.9999815,0.000002707946,0.000005951289,0.00000206038,0.000002881656,0.000004883818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000173151,0.00008813236,0.0002060008,0.00009329464,0.00001097677,0.0001088564,0.00001563537,0.0004551443,0.9905334,0.000109817,0.0002251455,0.0079805],"study_design_scores_gemma":[0.00008548755,0.001279293,0.00191633,0.0000088517,0.00004059267,0.0009064906,0.00001604526,0.003342519,0.9831155,0.00007773982,0.009201983,0.000009226195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767072,0.006924348,0.01191165,0.0002283834,0.00008349941,0.0001011425,0.0002259228,0.0002431936,0.003574694],"genre_scores_gemma":[0.9893916,0.002775263,0.003894298,0.0001250591,0.00002135733,0.00006284277,0.0002775542,0.00001661088,0.00343551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245708,"threshold_uncertainty_score":0.004167318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05681861596557435,"score_gpt":0.3426401445332967,"score_spread":0.2858215285677224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}