{"id":"W3133751538","doi":"10.1002/ctm2.337","title":"Aptamer‐SH2 superbinder‐based targeted therapy for pancreatic ductal adenocarcinoma","year":2021,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Cancer research; Pancreatic cancer; Stroma; Conjugate; Metastasis; Cancer; Immunofluorescence; Biology; Medicine; Chemistry; Pathology; Internal medicine; Antibody; Immunology; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001886556,0.0001144131,0.0002129527,0.00001878826,0.00005993012,0.000006294744,0.00006236148,0.0001285622,0.0001327327],"category_scores_gemma":[0.0001358565,0.00008806728,0.0001123201,0.00004953856,0.0002241032,0.000003220178,0.000007760791,0.00007850229,0.000002745944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":8.556275e-7,"about_ca_system_score_gemma":0.0001019115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005056891,"about_ca_topic_score_gemma":0.00001006173,"domain_scores_codex":[0.9990522,0.0000537148,0.0003278156,0.0003291366,0.000105055,0.000132053],"domain_scores_gemma":[0.9994729,0.0001196346,0.00003541447,0.0001389124,0.0001493323,0.00008384848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002178665,0.0004687918,0.7607424,0.00009325957,0.0005657974,0.00003642824,0.0001639321,0.00002590526,0.1962368,0.0006386533,0.007052522,0.03179687],"study_design_scores_gemma":[0.01152993,0.00310948,0.9261453,0.00009971207,0.0001622415,0.0000513735,0.0001932375,0.001643489,0.02616354,0.002572311,0.02793999,0.0003894729],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779406,0.01179557,0.004079855,0.005606735,0.0002369058,0.0001570705,0.00003403274,0.00000693273,0.0001422882],"genre_scores_gemma":[0.9936551,0.001038477,0.0009020863,0.002579178,0.0007938329,0.00002215937,0.0007276303,0.00001125005,0.0002702832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1700733,"threshold_uncertainty_score":0.359128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05681861596557435,"score_gpt":0.3426401445332967,"score_spread":0.2858215285677224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}