{"id":"W3133786494","doi":"10.1186/s12882-021-02524-6","title":"LAMA2 and LOXL4 are candidate FSGS genes","year":2021,"lang":"en","type":"article","venue":"BMC Nephrology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Toronto General Hospital; University Health Network; Public Health Ontario; University of Toronto","funders":"Hospital for Sick Children; McMaster University; Physicians' Services Incorporated Foundation; Toronto General and Western Hospital Foundation; Nephcure Foundation","keywords":"Focal segmental glomerulosclerosis; Medicine; Glomerular basement membrane; Candidate gene; Slit diaphragm; Pathology; Exome sequencing; Genetics; Biology; Podocyte; Gene; Glomerulonephritis; Phenotype; Kidney; Proteinuria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003598129,0.001028496,0.0003053116,0.001073093,0.0003250281,0.0004078837,0.0005653797,0.0008305206,0.004612428],"category_scores_gemma":[0.0007058081,0.0001200053,0.0004342957,0.000667692,0.0003196372,0.0002598875,0.0002497768,0.0002859535,0.0004020893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003604337,"about_ca_system_score_gemma":0.0004483684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009792802,"about_ca_topic_score_gemma":0.0008575076,"domain_scores_codex":[0.9998264,0.00004425174,0.00001537984,0.00004898333,0.00003673454,0.00002832819],"domain_scores_gemma":[0.9996667,0.0001261635,0.0001124196,0.00001101733,0.00003649108,0.00004734987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004702166,0.0004588472,0.6817724,0.0009721533,0.001088339,0.06087846,0.0005734354,0.002999157,0.1468852,0.004039136,0.004310728,0.09131998],"study_design_scores_gemma":[0.0005352795,0.0009888527,0.7818245,0.0005573992,0.002269617,0.0795094,0.0009348841,0.01368777,0.07772895,0.004780463,0.03710235,0.00008060722],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904829,0.004067289,0.002122882,0.0007645041,0.00004757821,0.0000391879,0.0006987457,0.0001103862,0.00166645],"genre_scores_gemma":[0.9937519,0.001035584,0.002724505,0.0001570577,0.00005374444,0.00002811385,0.0008526953,0.00001176025,0.00138466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004612428,"threshold_uncertainty_score":0.01543009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02659091121786232,"score_gpt":0.303228291428771,"score_spread":0.2766373802109087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}