{"id":"W3133786494","doi":"10.1186/s12882-021-02524-6","title":"LAMA2 and LOXL4 are candidate FSGS genes","year":2021,"lang":"en","type":"article","venue":"BMC Nephrology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Toronto General Hospital; University Health Network; Public Health Ontario; University of Toronto","funders":"Hospital for Sick Children; McMaster University; Physicians' Services Incorporated Foundation; Toronto General and Western Hospital Foundation; Nephcure Foundation","keywords":"Focal segmental glomerulosclerosis; Medicine; Glomerular basement membrane; Candidate gene; Slit diaphragm; Pathology; Exome sequencing; Genetics; Biology; Podocyte; Gene; Glomerulonephritis; Phenotype; Kidney; Proteinuria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001053237,0.00009544625,0.0002437905,0.00008214758,0.00005028022,0.00001333804,0.00005337975,0.0001147789,0.001036862],"category_scores_gemma":[0.0001556732,0.00008435977,0.00004614583,0.0001515178,0.0001211043,0.00001804976,0.0001584013,0.0001667028,0.0001651319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001950599,"about_ca_system_score_gemma":0.0001936791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000520935,"about_ca_topic_score_gemma":0.0005001255,"domain_scores_codex":[0.9990045,0.0001158007,0.0001343414,0.0003030494,0.0001563016,0.0002859631],"domain_scores_gemma":[0.9992701,0.000110162,0.00003188259,0.0003096233,0.0001121056,0.0001661358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005814011,0.0001656666,0.4203353,0.0002712821,0.0001599575,0.003033561,0.0001215586,0.000004723012,0.5438493,0.0005562332,0.01841404,0.01250697],"study_design_scores_gemma":[0.002748318,0.0003053988,0.5070138,0.0000242905,0.0001145722,0.001753976,0.0002301085,0.0004554644,0.05087724,0.000293326,0.4359992,0.0001843225],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884612,0.005680412,0.000186965,0.003302703,0.00006371715,0.0001495881,0.000005365346,0.00003382722,0.002116214],"genre_scores_gemma":[0.978963,0.001258261,0.003463232,0.00617667,0.0003067844,0.00003129488,0.00004957392,0.00003767198,0.009713537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.492972,"threshold_uncertainty_score":0.9998763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02659091121786232,"score_gpt":0.303228291428771,"score_spread":0.2766373802109087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}