{"id":"W3133950981","doi":"10.1101/2021.03.02.433653","title":"Metabolic independence drives gut microbial colonization and resilience in health and disease","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"Biotechnology and Biological Sciences Research Council; National Science Foundation; National Institutes of Health; Gastro-Intestinal Research Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; University of Calgary","keywords":"Microbiome; Dysbiosis; Metagenomics; Biology; Gut flora; Human Microbiome Project; Fecal bacteriotherapy; Disease; Genome; Gut microbiome; Mechanism (biology); Genetics; Evolutionary biology; Computational biology; Ecology; Human microbiome; Immunology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003956466,0.0002299207,0.0003273452,0.0003779275,0.0001850907,0.0006934518,0.0001210402,0.0003648722,0.001475172],"category_scores_gemma":[0.0003355679,0.0001571936,0.0002115386,0.0002974005,0.0005007627,0.0002580647,0.0006201495,0.0005641459,0.0002170292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002190338,"about_ca_system_score_gemma":0.0001901608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003337121,"about_ca_topic_score_gemma":0.0003112876,"domain_scores_codex":[0.999803,0.00003758633,0.000009774673,0.00006072473,0.00003917652,0.00004966205],"domain_scores_gemma":[0.9996769,0.00004013674,0.0001272868,0.00004036048,0.00002278239,0.00009253931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007450559,0.00007218269,0.02948156,0.00005953446,0.00004446016,0.0001138573,0.00005407992,0.0002655809,0.9649197,0.0003572854,0.0001480689,0.003738546],"study_design_scores_gemma":[0.00005466716,0.0008941795,0.6864697,0.00003330426,0.00008475417,0.0008758231,0.0005679735,0.005044607,0.2994382,0.0035768,0.002929356,0.00003057374],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967321,0.0004714213,0.001717834,0.0001609579,0.00002012103,0.000005373738,0.0003392272,0.00004446884,0.0005084954],"genre_scores_gemma":[0.9987387,0.0001031585,0.0007327842,0.00004647888,0.000008668451,0.000005159816,0.0001492115,0.000007697509,0.0002081355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475172,"threshold_uncertainty_score":0.004934967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007483154803887542,"score_gpt":0.2345921579384462,"score_spread":0.2271090031345586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}