{"id":"W3133958426","doi":"10.1146/annurev-immunol-093019-125918","title":"Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies","year":2021,"lang":"en","type":"article","venue":"Annual Review of Immunology","topic":"Eosinophilic Disorders and Syndromes","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"National Institute of Allergy and Infectious Diseases; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute of Diabetes and Digestive and Kidney Diseases; Fonds De La Recherche Scientifique - FNRS; Campaign Urging Research for Eosinophilic Disease; National Institutes of Health; Cincinnati Children's Hospital Medical Center; Mayo Foundation for Medical Education and Research","keywords":"Eosinophil; Immunology; Knockout mouse; Biology; Eosinophil peroxidase; Immune system; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005440356,0.0004410292,0.0004415892,0.0003831977,0.0001517761,0.0005848297,0.000339627,0.0008536316,0.001359709],"category_scores_gemma":[0.0002889685,0.0001707853,0.0002481556,0.0001879775,0.0007387699,0.0005857398,0.0004377776,0.001420574,0.0004366302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001734297,"about_ca_system_score_gemma":0.0002216923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009044058,"about_ca_topic_score_gemma":0.000203536,"domain_scores_codex":[0.9998649,0.0000404392,0.00001403487,0.00002414585,0.00003517566,0.00002119298],"domain_scores_gemma":[0.9999038,0.00002617694,0.00002800398,0.00001202304,0.00001002708,0.00001992873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009257239,0.0002908937,0.002402386,0.001700509,0.0001087924,0.002808037,0.0001611401,0.000311171,0.7116754,0.03353433,0.01300595,0.2330756],"study_design_scores_gemma":[0.0006231259,0.002941546,0.01327536,0.001456437,0.0004770606,0.03091792,0.0003707088,0.001644199,0.2569974,0.0157938,0.6754284,0.00007401084],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2513593,0.6385493,0.06568108,0.01701521,0.002620226,0.0004334759,0.001159344,0.001325873,0.02185624],"genre_scores_gemma":[0.3665102,0.5550141,0.05527297,0.009068109,0.001415016,0.0004557736,0.001037608,0.0001954475,0.01103075],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001359709,"threshold_uncertainty_score":0.004548669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01686350742692233,"score_gpt":0.2877162172907394,"score_spread":0.2708527098638171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}