{"id":"W3133966993","doi":"10.1016/j.arr.2021.101312","title":"Epigenetic enzymes: A role in aging and prospects for pharmacological targeting","year":2021,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Research Council Canada; National Research Center \"Kurchatov Institute\"","keywords":"Epigenetics; Epigenome; Histone; Biology; Methyltransferase; DNA methylation; Bioinformatics; Neuroscience; Medicine; Computational biology; Genetics; Gene; Methylation; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005147817,0.0003400157,0.001248893,0.0001941153,0.0001768504,0.0001151024,0.0003056669,0.0003526159,0.00001733158],"category_scores_gemma":[0.002551872,0.0002756198,0.0003388177,0.0004323867,0.00009189884,0.000004171492,0.0004149246,0.0005521467,0.000008801306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006371637,"about_ca_system_score_gemma":0.0002632475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001435597,"about_ca_topic_score_gemma":0.00002148204,"domain_scores_codex":[0.9959139,0.001450256,0.0008119351,0.0009216896,0.0002354124,0.0006668342],"domain_scores_gemma":[0.9988243,0.0003240565,0.0002199619,0.0003269556,0.0001555109,0.0001492204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003048304,0.0000436392,0.00002352561,0.007982451,0.00004070826,0.00002778568,0.00003062512,0.000001358989,0.004505345,0.00005074415,0.0004268749,0.9868639],"study_design_scores_gemma":[0.0001842154,0.0001453392,0.000007580402,0.005689472,0.00008241086,0.000003712543,0.00001697228,0.00001698214,0.001521098,0.0001012155,0.9919505,0.0002804658],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002672974,0.9962513,0.0002053185,0.00001865308,0.00007555552,0.002926876,0.00001094499,0.000006185388,0.0002378156],"genre_scores_gemma":[0.0002281899,0.9951463,0.001955216,0.00001878803,0.0005072383,0.001419014,0.0003093276,0.0000602223,0.0003557247],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9915237,"threshold_uncertainty_score":0.9999696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1450991806679187,"score_gpt":0.4684359127370261,"score_spread":0.3233367320691073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}