{"id":"W3133966993","doi":"10.1016/j.arr.2021.101312","title":"Epigenetic enzymes: A role in aging and prospects for pharmacological targeting","year":2021,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Research Council Canada; National Research Center \"Kurchatov Institute\"","keywords":"Epigenetics; Epigenome; Histone; Biology; Methyltransferase; DNA methylation; Bioinformatics; Neuroscience; Medicine; Computational biology; Genetics; Gene; Methylation; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008564884,0.00117746,0.001724799,0.001520424,0.0002750776,0.001177144,0.0009511327,0.001466994,0.004012505],"category_scores_gemma":[0.000819472,0.0003251508,0.0004135587,0.002039504,0.0007271657,0.001491912,0.0008981662,0.002311194,0.002494146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007720381,"about_ca_system_score_gemma":0.001081353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081003,"about_ca_topic_score_gemma":0.002879598,"domain_scores_codex":[0.9998223,0.00003344647,0.00002177132,0.00003178657,0.00006746245,0.00002323365],"domain_scores_gemma":[0.9996548,0.0001555225,0.00004326558,0.00001245764,0.00008494427,0.00004906094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001411708,0.00005859094,0.000142084,0.008893675,0.0001005752,0.0001915205,0.00004017559,0.0004330417,0.004073129,0.004645213,0.05534236,0.9259385],"study_design_scores_gemma":[0.00002858696,0.00007031248,0.0005592915,0.001428249,0.0001200901,0.0006100044,0.00004381797,0.0001161225,0.0007917977,0.003487685,0.9927251,0.00001893178],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004572657,0.9987298,0.0001853398,0.0002926426,0.0002576832,0.000002038094,0.00001346467,0.000007093913,0.0004662551],"genre_scores_gemma":[0.0003997126,0.9982779,0.0002146256,0.0001822155,0.0002889064,0.000004209938,0.00002278164,0.000001488597,0.000608218],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004012505,"threshold_uncertainty_score":0.01342314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1450991806679187,"score_gpt":0.4684359127370261,"score_spread":0.3233367320691073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}