{"id":"W3133986190","doi":"10.1158/1535-7163.mct-20-0510","title":"Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University College of the North","funders":"Janssen Research and Development","keywords":"Prostate cancer; Androgen receptor; Cancer research; Antagonist; Cancer; Internal medicine; Medicine; Receptor; Endocrinology; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002649611,0.0003909894,0.0004863769,0.0003216015,0.0001880461,0.000495659,0.0003706727,0.0005152554,0.001106953],"category_scores_gemma":[0.0001445154,0.0001872344,0.0003625697,0.0001758183,0.0002453882,0.0002420264,0.0002492418,0.0009393244,0.0005028659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004438332,"about_ca_system_score_gemma":0.0007532322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001157762,"about_ca_topic_score_gemma":0.004327101,"domain_scores_codex":[0.9998952,0.00001097551,0.000006330726,0.00001548434,0.0000408888,0.00003107412],"domain_scores_gemma":[0.999943,0.000005164038,0.000009073763,0.00000382049,0.00001011662,0.00002875516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005680864,0.0008003704,0.001260878,0.0002990928,0.00007218215,0.001241872,0.00009952894,0.001625016,0.9063563,0.003281922,0.004412045,0.07998262],"study_design_scores_gemma":[0.002445656,0.01685665,0.01522458,0.000177291,0.0002908375,0.009409244,0.00009356222,0.008501812,0.8455353,0.001140492,0.1002329,0.00009167717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9400693,0.02484873,0.00972908,0.002502868,0.0005528295,0.0006582902,0.001344754,0.000449219,0.01984496],"genre_scores_gemma":[0.9652076,0.01433098,0.0068322,0.001346669,0.00008554445,0.0001515379,0.001804598,0.00003806906,0.0102029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157762,"threshold_uncertainty_score":0.003703117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06884914067294168,"score_gpt":0.3620688245716197,"score_spread":0.293219683898678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}