{"id":"W3133986190","doi":"10.1158/1535-7163.mct-20-0510","title":"Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University College of the North","funders":"Janssen Research and Development","keywords":"Prostate cancer; Androgen receptor; Cancer research; Antagonist; Cancer; Internal medicine; Medicine; Receptor; Endocrinology; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002211933,0.0002274547,0.0004402568,0.0001397353,0.0001243382,0.0001024308,0.00006232928,0.00008748443,0.00001685021],"category_scores_gemma":[0.00004353117,0.0001945933,0.00008516998,0.0006966843,0.0002022834,0.0002094255,0.00003951746,0.0002493047,0.00000134731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003475062,"about_ca_system_score_gemma":0.001680125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001949485,"about_ca_topic_score_gemma":0.0006362066,"domain_scores_codex":[0.9981133,0.0001771746,0.0005541695,0.0004428752,0.0003865235,0.0003258983],"domain_scores_gemma":[0.9989807,0.00007753604,0.0002031448,0.0002493085,0.0003891203,0.0001002146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00133954,0.0002507559,0.007494822,0.0001696526,0.0006877509,0.0002658043,0.001972644,0.0001620022,0.9761092,0.0000695151,0.00001454901,0.01146378],"study_design_scores_gemma":[0.005193828,0.0005764134,0.002860569,0.000543117,0.0004918668,0.00001615781,0.002072644,0.0007873774,0.9858806,0.0001977277,0.001080756,0.000298962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832801,0.01271837,0.0001113294,0.002504294,0.0001653193,0.0007978876,0.000346895,0.00001411846,0.00006168341],"genre_scores_gemma":[0.97548,0.02137595,0.001533289,0.0004691902,0.00005850724,0.0001683976,0.0005256771,0.00004644308,0.0003425009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01116481,"threshold_uncertainty_score":0.7935286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06884914067294168,"score_gpt":0.3620688245716197,"score_spread":0.293219683898678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}