{"id":"W3133998413","doi":"10.1038/s41536-021-00124-4","title":"TP63 basal cells are indispensable during endoderm differentiation into proximal airway cells on acellular lung scaffolds","year":2021,"lang":"en","type":"article","venue":"npj Regenerative Medicine","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Lunenfeld-Tanenbaum Research Institute; Sinai Health System; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Decellularization; Endoderm; Cell biology; Progenitor cell; Stem cell; Cellular differentiation; Biology; Transplantation; Anatomy; Medicine; Internal medicine; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003715848,0.0007481149,0.001306974,0.0004271753,0.0004038425,0.00003660117,0.0001826855,0.0003071315,0.001407824],"category_scores_gemma":[0.0002453056,0.0005483486,0.0001962489,0.0007727746,0.0003430281,0.000129969,0.000106201,0.0006374722,0.00009807577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004563735,"about_ca_system_score_gemma":0.00019335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003477653,"about_ca_topic_score_gemma":0.000030761,"domain_scores_codex":[0.995908,0.0002768158,0.0007876808,0.001089296,0.001182141,0.0007560407],"domain_scores_gemma":[0.9976004,0.0001446017,0.0003038425,0.0008194433,0.0005440295,0.0005876661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001901052,0.0003800925,0.001620927,0.000623696,0.0002974654,0.001098376,0.002667189,0.0009266979,0.981557,0.0005532146,0.00952238,0.000562854],"study_design_scores_gemma":[0.006141767,0.0008880327,0.004365508,0.001761913,0.000356518,0.0001016581,0.0009274127,0.004778239,0.9759163,0.00002141889,0.004241894,0.0004993851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652032,0.01524471,0.006989226,0.007566635,0.002637291,0.001005769,0.00002225677,0.0002448761,0.001086013],"genre_scores_gemma":[0.9306861,0.0004894406,0.00171832,0.000381438,0.003879553,0.0001015056,0.0003489626,0.0001328838,0.0622618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06117579,"threshold_uncertainty_score":0.9996968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01222520383024835,"score_gpt":0.2503606764088374,"score_spread":0.238135472578589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}