{"id":"W3134014622","doi":"10.1186/s13014-021-01935-x","title":"Gastrointestinal and genitourinary toxicity profiles of metformin versus placebo in men with prostate cancer receiving prostate radiotherapy: interim toxicity results of a double-blinded, multicenter, phase II randomized controlled trial","year":2021,"lang":"en","type":"article","venue":"Radiation Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary; University of Manitoba; CancerCare Manitoba","funders":"Alberta Cancer Foundation; CancerCare Manitoba Foundation","keywords":"Medicine; Interim analysis; Prostate cancer; Placebo; Metformin; Genitourinary system; Radiation therapy; Internal medicine; Toxicity; Urology; Prostate; Randomized controlled trial; Gastroenterology; Oncology; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003940828,0.001864606,0.00369306,0.0005653048,0.0005560438,0.001246066,0.0008316926,0.001875614,0.003878334],"category_scores_gemma":[0.004035141,0.0008344328,0.003284395,0.0004556596,0.0008656667,0.001063017,0.0003537742,0.002360145,0.0005248672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006153563,"about_ca_system_score_gemma":0.001081065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003687828,"about_ca_topic_score_gemma":0.001000501,"domain_scores_codex":[0.9978942,0.001469644,0.0001610239,0.0002039812,0.0001226408,0.0001484701],"domain_scores_gemma":[0.9977306,0.000801541,0.0007497668,0.000171124,0.0001562651,0.0003907047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9845888,0.004965505,0.0005132934,0.0002584144,0.0008054311,0.00001751889,0.00002766712,0.0001961911,0.001479188,0.00002411246,0.000156409,0.006967375],"study_design_scores_gemma":[0.8235956,0.1717867,0.00242613,0.00003175891,0.0008477549,0.00002443247,0.00001518485,0.000391608,0.0005535083,0.00008358499,0.0002277458,0.00001585356],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904029,0.003703885,0.0007332924,0.0002801148,0.0002701372,0.003086933,0.0005753908,0.00009221591,0.0008551553],"genre_scores_gemma":[0.9897776,0.001930755,0.00189809,0.0004956445,0.000336974,0.003725926,0.0006065233,0.0000255737,0.001202936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003940828,"threshold_uncertainty_score":0.0208413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04039209264867043,"score_gpt":0.3883933773181183,"score_spread":0.3480012846694479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}