{"id":"W3134015568","doi":"10.1038/s41467-021-21718-y","title":"Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Georgia Clinical and Translational Science Alliance; Weill Cornell Medical College; National Center for Research Resources; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Health and Human Services; Vertex Pharmaceuticals; Cystic Fibrosis Foundation; Deutsche Forschungsgemeinschaft","keywords":"Biofilm; Staphylococcus aureus; Microbiology; Glycolysis; Bacteria; Immune system; Biology; Pathogen; Human pathogen; Extracellular; Metabolite; Staphylococcal infections; Chemistry; Enzyme; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000972686,0.0002891088,0.000201077,0.0001194167,0.0000907213,0.0002068228,0.00007907867,0.0002131616,0.000975113],"category_scores_gemma":[0.0001211218,0.00007593176,0.0002179563,0.00008635056,0.0001118515,0.00008438735,0.0003066603,0.0003882726,0.0002079691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000143613,"about_ca_system_score_gemma":0.0001552425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004664086,"about_ca_topic_score_gemma":0.0007393771,"domain_scores_codex":[0.999819,0.00003279397,0.00001341526,0.00002504438,0.00005959246,0.0000501155],"domain_scores_gemma":[0.9998852,0.00001760716,0.00003141906,0.00001291809,0.0000199875,0.00003278145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004704584,0.00001920836,0.0002352272,0.00001297193,0.000001892017,0.00003380328,0.000008262612,0.00001224051,0.9991277,0.00001633836,0.00002236452,0.0004630163],"study_design_scores_gemma":[0.00002249517,0.001470202,0.0364612,0.00001611343,0.00001227546,0.0005652263,0.0001219534,0.0007681765,0.958684,0.00006561554,0.00180559,0.000007225536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974362,0.00045719,0.0006248287,0.0001054788,0.0000240394,0.00002254583,0.0001556529,0.00003087574,0.001143266],"genre_scores_gemma":[0.9976101,0.0002665652,0.0007115566,0.0001203111,0.000009768622,0.00001911373,0.0002636149,0.000007798504,0.0009912795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000975113,"threshold_uncertainty_score":0.003262043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03001281397283273,"score_gpt":0.3280384087086848,"score_spread":0.2980255947358521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}