{"id":"W3134015568","doi":"10.1038/s41467-021-21718-y","title":"Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Georgia Clinical and Translational Science Alliance; Weill Cornell Medical College; National Center for Research Resources; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Health and Human Services; Vertex Pharmaceuticals; Cystic Fibrosis Foundation; Deutsche Forschungsgemeinschaft","keywords":"Biofilm; Staphylococcus aureus; Microbiology; Glycolysis; Bacteria; Immune system; Biology; Pathogen; Human pathogen; Extracellular; Metabolite; Staphylococcal infections; Chemistry; Enzyme; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006144512,0.0002983768,0.0004623988,0.0003871284,0.0005540033,0.0001307537,0.00099437,0.0005876338,0.0001087718],"category_scores_gemma":[0.00108474,0.0002876319,0.0002022824,0.001196927,0.0003747536,0.0006484671,0.0003953404,0.001640965,0.00006541483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001992231,"about_ca_system_score_gemma":0.0005177038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001791708,"about_ca_topic_score_gemma":0.0002157517,"domain_scores_codex":[0.9976001,0.000748993,0.0004904111,0.0003845679,0.0003755219,0.0004004267],"domain_scores_gemma":[0.9945585,0.0005680833,0.0002773555,0.003474587,0.0009166414,0.0002048395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009176919,0.0006491975,0.002074293,0.0000424841,0.0001576458,0.00003866309,0.001232553,0.000003624945,0.9831945,0.005446728,0.002310755,0.003931858],"study_design_scores_gemma":[0.002811835,0.0002219274,0.3548078,0.0002999216,0.0003254615,0.000098514,0.004626596,0.0003264975,0.4266948,0.0004923005,0.2086016,0.0006926766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652826,0.02197444,0.0001256833,0.00812197,0.0002333149,0.0006127884,0.0001728314,0.0002344441,0.003241912],"genre_scores_gemma":[0.9844275,0.002492266,0.009969099,0.001369073,0.00005766136,0.00008064519,0.0009727656,0.00005286406,0.0005781931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5564997,"threshold_uncertainty_score":0.9999576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03001281397283273,"score_gpt":0.3280384087086848,"score_spread":0.2980255947358521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}