{"id":"W3134022400","doi":"10.1016/j.celrep.2021.108815","title":"Most non-canonical proteins uniquely populate the proteome or immunopeptidome","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada First Research Excellence Fund","keywords":"Proteome; Biology; Major histocompatibility complex; Computational biology; Genetics; Gene; Human proteome project; Gene isoform; Ribosome; RNA; Cell biology; Proteomics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002105644,0.0006369565,0.0002610245,0.00041623,0.0001943245,0.0004192051,0.0002259007,0.0002304127,0.00137555],"category_scores_gemma":[0.0002094902,0.0001361251,0.0002127633,0.0002773738,0.0002227685,0.0002199127,0.0002138433,0.0003416564,0.0007221943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001853137,"about_ca_system_score_gemma":0.0002004369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002243436,"about_ca_topic_score_gemma":0.000436098,"domain_scores_codex":[0.9998362,0.0000161956,0.000009337658,0.00006106422,0.0000505827,0.00002662117],"domain_scores_gemma":[0.9998492,0.00004406325,0.00004072356,0.00001795652,0.00002324278,0.00002478976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007976381,0.000008763604,0.0007984699,0.00004155223,0.000009828623,0.00006087969,0.000009234528,0.00003051246,0.996967,0.00007282802,0.00003270685,0.001888465],"study_design_scores_gemma":[0.00001164828,0.0001369192,0.0236241,0.00000864236,0.00003315205,0.0008649266,0.0000317394,0.001125349,0.9696915,0.0002755063,0.004189542,0.000006969476],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735285,0.003554763,0.01631412,0.0001228854,0.00005105875,0.00005722673,0.002489307,0.0001728843,0.003709219],"genre_scores_gemma":[0.9596938,0.003322381,0.02721551,0.0001668701,0.00003586387,0.0001052682,0.005399943,0.0001427767,0.003917628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00137555,"threshold_uncertainty_score":0.004601717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708629814517891,"score_gpt":0.2704187972619336,"score_spread":0.2533324991167547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}