{"id":"W3134040055","doi":"10.1007/s43440-021-00240-4","title":"Effects of Gαi2 and Gαz protein knockdown on alpha2A-adrenergic and cannabinoid CB1 receptor regulation of MEK-ERK and FADD pathways in mouse cerebral cortex","year":2021,"lang":"en","type":"article","venue":"Pharmacological Reports","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Ministerio de Ciencia, Innovación y Universidades","keywords":"Cannabinoid receptor; Chemistry; MAPK/ERK pathway; Cell biology; Neuroscience; Cannabinoid; Receptor; Signal transduction; Endocrinology; Internal medicine; Biology; Medicine; Biochemistry; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004489598,0.0002222658,0.0004331353,0.0001729846,0.0001242794,0.00003011679,0.0001141975,0.0001171043,0.0001064267],"category_scores_gemma":[0.001494195,0.0001836849,0.00004714938,0.0005035787,0.0006752471,0.0001854123,0.0003018298,0.0003768314,0.000001146504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002845334,"about_ca_system_score_gemma":0.0001229008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001751843,"about_ca_topic_score_gemma":0.000003357478,"domain_scores_codex":[0.9969689,0.0006458815,0.0005491551,0.000951184,0.0004699745,0.000414884],"domain_scores_gemma":[0.9986472,0.0005616202,0.0003010058,0.0001667671,0.00008174981,0.0002416797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000218548,0.0004213057,0.003690835,0.0001401832,0.00000471182,0.001523932,0.00008171218,0.00001383501,0.9922862,0.0001729108,0.0001257988,0.001320003],"study_design_scores_gemma":[0.001011389,0.0006520558,0.03924346,0.0000333302,0.0000200418,0.0002033366,0.000008402424,0.0002909549,0.9579381,0.0002958115,0.0001493945,0.0001536747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981934,0.0002223527,0.000001995878,0.0002850604,0.0001981711,0.0008832549,0.00001301498,0.00003252268,0.0001702357],"genre_scores_gemma":[0.9982409,0.0005409551,0.00003181358,0.0004898476,0.00002924318,0.000101246,0.00000131028,0.00001555606,0.0005490987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03555263,"threshold_uncertainty_score":0.7490454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03462581369059078,"score_gpt":0.3094547979546391,"score_spread":0.2748289842640483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}