{"id":"W3134040055","doi":"10.1007/s43440-021-00240-4","title":"Effects of Gαi2 and Gαz protein knockdown on alpha2A-adrenergic and cannabinoid CB1 receptor regulation of MEK-ERK and FADD pathways in mouse cerebral cortex","year":2021,"lang":"en","type":"article","venue":"Pharmacological Reports","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Ministerio de Ciencia, Innovación y Universidades","keywords":"Cannabinoid receptor; Chemistry; MAPK/ERK pathway; Cell biology; Neuroscience; Cannabinoid; Receptor; Signal transduction; Endocrinology; Internal medicine; Biology; Medicine; Biochemistry; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002049301,0.0006125896,0.0004643527,0.0004828684,0.0004039657,0.0003840648,0.0004101004,0.0003968259,0.002390168],"category_scores_gemma":[0.0001141549,0.0003112796,0.0005511758,0.0003232577,0.0005891824,0.0004365809,0.0002204214,0.001332258,0.0004956982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005301883,"about_ca_system_score_gemma":0.0005295728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00433494,"about_ca_topic_score_gemma":0.005119186,"domain_scores_codex":[0.9997501,0.00001582238,0.00002124245,0.00006036337,0.00003845296,0.0001140182],"domain_scores_gemma":[0.9998893,0.00001309549,0.00002244546,0.00001166381,0.00001305014,0.00005062834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005607898,0.00007752376,0.00007981394,0.00006043046,0.00001673131,0.00007848263,0.00004554997,0.00007014209,0.9976793,0.000221208,0.0001532247,0.0009568344],"study_design_scores_gemma":[0.00007022184,0.0003130033,0.003510786,0.000008153737,0.00007223057,0.0001393367,0.0001286142,0.0007161023,0.9931337,0.0001098598,0.001787771,0.00001029117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911582,0.002303179,0.002107671,0.0004344194,0.0001749636,0.00004619853,0.00091615,0.0001547394,0.00270446],"genre_scores_gemma":[0.9839004,0.002887971,0.002366986,0.0002208535,0.0000341342,0.0001423618,0.001139411,0.00007385859,0.009234012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00433494,"threshold_uncertainty_score":0.008619368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03462581369059078,"score_gpt":0.3094547979546391,"score_spread":0.2748289842640483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}