{"id":"W3134065403","doi":"10.3390/cancers13051043","title":"Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; Research Manitoba","keywords":"Chromatin; Mitosis; Chromosome instability; Biology; Cell biology; PLK1; Histone; Histone H2B; Carcinogenesis; Chromosome segregation; Genome instability; Cell cycle; Chromosome; Cancer research; Genetics; Cell; Gene; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007655726,0.0002988207,0.0001987095,0.000240099,0.0001267919,0.0003091717,0.0001417129,0.0002449926,0.001857211],"category_scores_gemma":[0.00006560901,0.0001286952,0.0001841882,0.0001272479,0.0001686873,0.000148178,0.0001671311,0.0003261179,0.000337954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002589068,"about_ca_system_score_gemma":0.0001636731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008904015,"about_ca_topic_score_gemma":0.00116133,"domain_scores_codex":[0.9999149,0.0000113404,0.00001271504,0.00001913665,0.00002284598,0.0000189832],"domain_scores_gemma":[0.9999198,0.000009239453,0.00002185059,0.000009143931,0.000005529012,0.00003453774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008687189,0.00002768881,0.0001532512,0.00002338475,0.00000447221,0.00005933432,0.000006650805,0.00004805947,0.9986563,0.0001343334,0.00003079631,0.0007687711],"study_design_scores_gemma":[0.000009943472,0.000123895,0.005153003,0.000005381245,0.00001428291,0.0001872715,0.00002190638,0.001213781,0.9903693,0.00006442383,0.002833358,0.000003571806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944177,0.001164494,0.001803784,0.00007068038,0.00002916979,0.00001506273,0.0006741569,0.0001078572,0.001717214],"genre_scores_gemma":[0.9923695,0.0007197411,0.0007670514,0.0000260265,0.0000044656,0.00001841537,0.0006514982,0.00002235779,0.005420833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001857211,"threshold_uncertainty_score":0.006213009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01649540521891703,"score_gpt":0.2649165601242715,"score_spread":0.2484211549053545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}